WIREs Mechanisms of Disease

WIREs Mechanisms of Disease is a bimonthly review journal launched by Wiley in 2021 through the merger of WIREs Systems Biology and Medicine and WIREs Developmental Biology, publishing interdisciplinary reviews on the molecular and cellular mechanisms of disease, with a 2025 Journal Impact Factor of 5.4《威利跨学科评论-疾病机制》（WIREs Mechanisms of Disease）是（Wiley）于 2021 年将（WIREs Systems Biology and Medicine）与（WIREs Developmental Biology）合并创办的双月刊综述期刊，刊载疾病分子与细胞机制的多学科综述，2025 年影响因子为 5.4。

Scope

• It is a multidisciplinary international journal concerned with the approaches needed to clarify disease mechanisms该刊是一本多学科国际期刊，关注阐明疾病机制所需的研究途径。
• It seeks review papers of widespread interest that combine tools from several biological fields to clarify molecular and cellular pathophysiology across medical fields该刊寻求具有广泛关注度、整合多个生物学领域工具以阐明各医学领域分子与细胞病理生理机制的综述。
• It focuses on genetic mutations and environmental perturbations associated with the development and progression of disease, and on distinguishing detrimental from compensatory molecular pathways重点研究疾病发生与进展相关的基因突变和环境扰动，并区分有害通路与代偿性分子通路。
• Key medical fields include cancer, congenital diseases, immune system diseases, infectious diseases, metabolic diseases, neurological diseases, cardiovascular diseases, endocrine diseases and reproductive system diseases重点医学领域包括癌症、先天性疾病、免疫系统疾病、感染性疾病、代谢性疾病、神经系统疾病、心血管疾病、内分泌疾病与生殖系统疾病。
• Topical coverage includes genomics, genetics, epigenetics, transcriptomics and proteomics主题覆盖基因组学、遗传学、表观遗传学、转录组学与蛋白质组学。
• Developmental biology, histology and human cellular models, histopathology and stem cell biology are also covered还包括发育生物学、组织学与人类细胞模型、组织病理学及干细胞生物学。
• Further topics include physiology, metabolism and metabolomics, physiopathology, microbiology, environmental biology, toxicology, disease models, mechanobiology, biomedical engineering and computational models其他主题包括生理学、代谢与代谢组学、病理生理学、微生物学、环境生物学、毒理学、疾病模型、力学生物学、生物医学工程与计算模型。

History

• The title was created in 2021 by merging WIREs Systems Biology and Medicine, launched in 2009, with WIREs Developmental Biology, launched in 2012该刊于 2021 年由 2009 年创刊的（WIREs Systems Biology and Medicine）与 2012 年创刊的（WIREs Developmental Biology）合并而成。^[1]
• Volume numbering continued from WIREs Systems Biology and Medicine, so the first volume under the new title was volume 13 in 2021, and the journal reached volume 18 in 2026卷号沿用（WIREs Systems Biology and Medicine），新刊首卷为 2021 年第 13 卷，2026 年已至第 18 卷。
• It is published by Wiley Periodicals LLC as part of the WIREs series, which combines features of encyclopedic reference works and review journals in an online format该刊由（Wiley Periodicals LLC）出版，属于（WIREs）系列，该系列以在线形式融合百科全书式参考工具与综述期刊的特点。
• Reviews are invited, written and peer-reviewed by experts, and authors submit article proposals to the editors rather than unsolicited manuscripts综述由专家受邀撰写并参与同行评审，作者向编辑提交文章提案而非直接投递未经邀请的稿件。
• Its 2025 Journal Impact Factor is 5.4, its acceptance rate is 32 percent, and the median time from submission to first decision is 135 days该刊 2025 年影响因子为 5.4，录用率为 32%，投稿至首次决定的中位时间为 135 天。
• It is indexed in MEDLINE/PubMed, the Web of Science, Chemical Abstracts Service and Scopus, and articles published before the 2021 merger remain listed under the original journals该刊被（MEDLINE/PubMed）、（Web of Science）、（Chemical Abstracts Service）与（Scopus）收录，2021 年合并前发表的文章仍列于原刊名下。

Editors

• Roxana Deleanu of the Medical University of Innsbruck in Austria is editor-in-chief, with interests in stem cell research, neurodegenerative disease and human cellular models主编（Roxana Deleanu）任职于奥地利因斯布鲁克医科大学，研究兴趣包括干细胞、神经退行性疾病与人类细胞模型。
• Justus Anumonwo of the University of Michigan works on the molecular and cellular physiology of cardiovascular disease as an editor编辑（Justus Anumonwo）任职于（University of Michigan），研究心血管疾病的分子与细胞生理学。
• Fernando Cardona of the Instituto de Biomedicina de Valencia and CSIC in Spain serves as an editor for the molecular basis of human diseases编辑（Fernando Cardona）任职于西班牙（Instituto de Biomedicina de Valencia）与（CSIC），负责人类疾病分子基础方向。
• The editor team also includes Dechao Feng, Diego A. Forero, Gabriel G. Haddad and Andrei Surguchov, covering genomics, immuno-oncology, neuropsychiatric disorders, cardiovascular genetics and metabolic disease编辑团队还包括（Dechao Feng）、（Diego A. Forero）、（Gabriel G. Haddad）与（Andrei Surguchov），覆盖基因组学、免疫肿瘤学、神经精神疾病、心血管遗传学与代谢性疾病。
• Its advisors include Cuihua Liu of the Chinese Academy of Sciences, Mark Mercola of Stanford University, Joseph H. Nadeau of the Maine Medical Center Research Institute, Manju Narwal of Penn State University and Shankar Subramaniam of the University of California San Diego顾问包括中国科学院（Cuihua Liu）、（Stanford University）的（Mark Mercola）、（Maine Medical Center Research Institute）的（Joseph H. Nadeau）、（Penn State University）的（Manju Narwal）与（University of California San Diego）的（Shankar Subramaniam）。
• All reviews are peer-reviewed by experts, and the journal describes its content as review articles that synthesize key findings from primary research所有综述均由专家同行评审，该刊将内容定位为综合原始研究关键发现的综述文章。