Science Signaling

Science Signaling is a weekly online journal of the life sciences that publishes studies uncovering the basic mechanisms underlying biological processes in all organisms, with a focus on signal transduction and regulatory biology in physiology and disease.《科学—信号转导》（Science Signaling）是生命科学领域的在线周刊，发表揭示所有生物体生物过程基础机制的研究，聚焦生理与疾病中的信号转导与调控生物学。

Scope

The journal's stated aim is to publish original research that advances understanding of cell signaling and regulatory biology, with its official scope covering:刊物官方宗旨为发表推进细胞信号转导与调控生物学理解的原创研究，官方声明的征稿范围包括：

• Signal transduction mechanisms: research on the molecular mechanisms by which cells and organisms sense, transmit, and respond to extracellular and intracellular cues, including receptor signaling, second messengers, protein phosphorylation, and post-translational modifications.信号转导机制： 关于细胞与生物体感知、传递与响应胞外胞内信号的分子机制研究，涵盖受体信号、第二信使、蛋白质磷酸化与翻译后修饰等。
• Regulatory biology: studies on the regulatory networks and pathways that control gene expression, cell cycle, differentiation, metabolism, immune responses, and other cellular and organismal processes.调控生物学： 关于控制基因表达、细胞周期、分化、代谢、免疫应答及其他细胞与生物体过程的调控网络与通路的研究。
• Physiology and disease: work that provides new insights into physiology, delineates mechanisms that cause disease, identifies potential therapeutic targets and strategies, and characterizes the effects of drugs on signaling and regulatory systems.生理与疾病： 提供生理学新洞见、阐明致病机制、识别潜在治疗靶点与策略并表征药物对信号与调控系统影响的工作。
• Systems and quantitative biology: research that integrates signaling data into quantitative and systems-level understanding, including network analysis, mathematical modeling, and the application of computational approaches to regulatory biology.系统与定量生物学： 将信号数据整合为定量与系统层面理解的研究，涵盖网络分析、数学建模以及计算方法在调控生物学中的应用等。
• Cross-disciplinary coverage: studies spanning biochemistry, cell and molecular biology, immunology, neuroscience, pharmacology, physiology and medicine, microbiology, botany, and bioinformatics where they bear on signaling and regulation.跨学科覆盖： 涉及生物化学、细胞与分子生物学、免疫学、神经科学、药理学、生理学与医学、微生物学、植物学与生物信息学且与信号转导和调控相关的研究。
• Article types: original Research Articles presenting major advances in regulatory biology, Research Resources, Focuses, and Reviews, most Focuses and Reviews being solicited by the editors.栏目设置： 接受呈现调控生物学重要进展的原创研究文章、研究资源、焦点文章与综述，其中多数焦点文章与综述由编辑约稿。

History

• Origin as Science's STKE: the journal was established in 1999 by the American Association for the Advancement of Science under the name Science's STKE (Signal Transduction Knowledge Environment), an online resource focused on signal transduction research. It published continuously under that title through 2007, with its final issue being volume 2007, issue 417.Science's STKE 前身： 该刊 1999 年由美国科学促进会以《Science's STKE》（信号转导知识环境）之名创立，是聚焦信号转导研究的在线资源。该刊以此名称持续出版至 2007 年，最后一期为 2007 年卷第 417 期。
• Relaunch as Science Signaling: on January 8, 2008, the journal was renamed Science Signaling and its volume numbering restarted at 1, becoming a full peer-reviewed research journal as part of the Science family while retaining its focus on signal transduction and regulatory biology.更名为 Science Signaling： 2008 年 1 月 8 日该刊更名为《Science Signaling》，卷号从第 1 卷重新开始，成为《科学》系列中一份完整的同行评审研究期刊，同时保持其对信号转导与调控生物学的聚焦。
• Online-first publication: the journal has been published online throughout its history, with articles released on a weekly basis and organized into regular issues and virtual issues on thematic topics.在线优先出版： 该刊自创立以来一直在线出版，文章每周发布并按常规期与主题虚拟期组织。

Editors

As a journal in the Science family, Science Signaling is led by the Science family editor-in-chief and an in-house editorial team of professional PhD-level editors:作为 Science 系列期刊，本刊由 Science 系列主编与具备博士学位的内部专业编辑团队领导：

• Editor-in-chief: Holden Thorp, PhD, who serves as editor-in-chief of the Science family of journals and oversees editorial direction across Science, Science Signaling, and the other Science journals.主编： 霍尔登·索普（Holden Thorp），哲学博士，担任 Science 系列期刊主编，监督《科学》《科学—信号转导》及其他 Science 期刊的编辑方向。
• In-house editorial team: the journal is managed by a team of professional in-house editors, each with a doctoral background in a relevant life science discipline and responsibility for a defined subject area within the journal's scope.内部编辑团队： 该刊由专业内部编辑团队管理，每位编辑均具备相关生命科学学科博士背景，负责刊物范围内一个特定学科方向。
• Review model: submissions are first assessed by an in-house editor for fit, novelty, and broad significance, and those that pass initial screening are sent for external peer review before a final editorial decision is made.评审模式： 投稿先由内部编辑评估适配性、新颖性与广泛意义，通过初步筛选者送外部同行评审后再做最终编辑决定。