Proteins: Structure, Function, and Bioinformatics

Proteins: Structure, Function, and Bioinformatics is an international journal of protein science, published by Wiley and established in 1986 by Cyrus Levinthal.《蛋白质结构与功能及生物信息学》是一份蛋白质科学的国际期刊，由 Wiley 出版，1986 年由（Cyrus Levinthal）创办。

The title publishes experimental and analytic work across protein structure, function, computation, genetics and design.该刊发表蛋白质结构、功能、计算、遗传学与设计方面的实验与分析工作。

In the 2025 edition of the journal citation report it holds an impact factor of 3.3 and stands in the second quartile of biophysics.在 2025 年版期刊引证报告中，该刊的影响因子为 3.3，在生物物理学类目中列第二区。

Scope

• Protein structure lies at the centre of the journal, and the elucidation of three-dimensional folds by experimental means is a standing subject.蛋白质结构是该刊的中心，用实验手段解析三维折叠是常设题目。

• Protein function is treated in the same breadth, and work that ties a structure to what a molecule does inside a cell is admitted.蛋白质功能得到同等幅度的处理，把结构与分子在细胞内的作为联系起来的论文也在接纳之列。

• Computation forms a large part of what the journal prints, and methods for predicting a fold from a sequence are taken.计算构成该刊相当大一部分内容，自序列预测折叠的方法受到收载。

• Molecular dynamics and other simulation techniques are covered, and studies that model the motion of a protein over time appear regularly.分子动力学与其他模拟技术得到覆盖，模拟蛋白质随时间运动的论文定期出现。

• Protein genetics is admitted, and work on the way mutation alters structure and function belongs to the subject.蛋白质遗传学也在接纳之列，突变改变结构与功能的方式属于选题范围。

• Protein design is named among the areas, and papers on engineered sequences and on synthetic folds are welcomed.蛋白质设计是点名领域之一，关于工程化序列与人工折叠的论文受到欢迎。

• The journal encourages reports that set out new experimental or computational approaches for interpreting and understanding data.该刊鼓励提出新的实验或计算方法、用以解读与理解数据的报告。

• Biophysical chemistry forms part of the ground the journal works over, and studies of folding, stability and binding are taken.生物物理化学是该刊工作范围的一部分，关于折叠、稳定性与结合的考察受到收载。

• Structural genomics appears in the scope, and work on families of related proteins is given room.结构基因组学见于收稿范围，关于相关蛋白质家族的工作得到空间。

• Macromolecular assemblies are treated as a subject, and the journal carries studies of complexes built from several chains.大分子组装体自成一个选题，该刊刊载由多条链构成的复合物研究。

• Enzymes and their mechanisms are admitted, and kinetic work joined to structure is a familiar kind of contribution.酶及其机制也在接纳之列，把动力学工作与结构结合的论文是常见的一类来稿。

• The journal takes part in community experiments, and it publishes assessments from the blind prediction exercises that the field runs.该刊参与学界的集体实验，并发表本领域盲测活动中的评估结果。

• Reviews and invited pieces are carried, and a review is expected to gather the evidence of a field rather than to serve a single laboratory.该刊刊载综述与邀约文章，所选综述要求汇集某一领域的证据，而非服务单个实验室。

• Short communications give authors room to report a single finding, and prediction reports have their own place in the journal.短篇通讯让作者有余地报告单一发现，预测报告在该刊也有自己的位置。

• The readership is drawn from biochemistry, crystallography, biophysics and computational biology, and it reaches laboratories in many countries.读者来自生物化学、晶体学、生物物理学与计算生物学，遍及多国的实验室。

History

• The journal was established in 1986 by Cyrus Levinthal, and the first volume was gathered in that year.该刊于 1986 年由（Cyrus Levinthal）创办，第 1 卷也在当年成册。

• The founding publisher was Alan R. Liss in New York, a house that was later absorbed into the Wiley group.创始出版方是纽约的 Alan R. Liss，该社后来并入 Wiley 集团。

• The current imprint names Wiley-Liss in New York, and the title is issued today under the wider Wiley banner.现行出版信息写的是纽约的 Wiley-Liss，该刊如今在更大的 Wiley 品牌之下发行。

• The journal comes out twelve times a year, and the monthly rhythm has been kept for many volumes.该刊每年出版十二期，这一月刊的节奏已保持了许多卷。

• The print number is 0887-3585 and the electronic number is 1097-0134, and the abbreviation used in the indexes is simply Proteins.印刷版编号为 0887-3585，电子版编号为 1097-0134，索引中使用的缩写就是 Proteins。

• MEDLINE and PubMed have indexed the title from the first volume of 1986, and it also appears in Index Medicus.MEDLINE 与 PubMed 自 1986 年的第 1 卷起收录该刊，它也见于 Index Medicus。

• The impact indicator has moved from 3.756 and 4.088 to 3.2 and 2.8, and it stood at 3.3 in the 2025 edition.影响因子从 3.756 与 4.088 变为 3.2 与 2.8，在 2025 年版为 3.3。

• A little under two fifths of the papers are free to read on publication, and the journal runs a hybrid open access model.不到五分之二的论文在出版时即可免费阅读，该刊实行混合开放获取模式。

• The citation half life of the title is long, at close to seventeen years, which suits a field where a structure may be revisited for a generation.该刊的引用半衰期较长，接近十七年，这适合一个结构可被重新审视一代人的领域。

• Special issues are gathered around a theme, and one recent volume was given over to the eighth round of a community blind prediction exercise.专刊围绕某一主题汇集，某近卷即交由一场集体盲测活动的第八轮。

• Editorial leadership has passed through several hands since the founding, and the journal has kept its place among the standard outlets for protein science.自创刊以来编辑领导权历经多人之手，该刊始终保有其作为蛋白质科学标准发表平台之一的位置。

• The journal carries work on the comparison of structures, and studies that draw a family of proteins together are admitted.该刊刊载结构比较方面的工作，把某一蛋白质家族汇到一起的研究也在接纳之列。

• Work on protein interaction networks appears, and the journal takes studies of how partners recognise one another.蛋白质相互作用网络的工作也有出现，该刊收载伙伴之间如何相互识别的研究。

• Machine learning has entered the field, and the journal carries work in which a model is trained to predict a property of a protein.机器学习已进入这一领域，该刊刊载训练模型以预测蛋白质某项性质的工作。

• The journal is read by structural biologists and by computational scientists, and it has kept that dual audience in view for nearly four decades.该刊的读者既有结构生物学家也有计算科学家，近四十年来一直兼顾这两类读者。

Editors

• The editor-in-chief is Nikolay Dokholyan, a researcher in computational and experimental protein science.主编是（Nikolay Dokholyan），一位从事计算与实验蛋白质科学的研究者。

• Three associate editors support the title, Ivet Bahar of the Laufer Center at Stony Brook University, Michael Feig of Michigan State University and Modesto Orozco of the University of Barcelona.三位副编辑协助该刊，即石溪大学劳弗中心的（Ivet Bahar）、密歇根州立大学的（Michael Feig）与巴塞罗那大学的（Modesto Orozco）。

• Dedicated editors handle the community prediction exercises, with a capri editor and a casp editor named on the board.社区预测活动由专任编辑处理，编委会中设有一位 CAPRI 编辑与一位 CASP 编辑。

• The structural bioinformatics exercises bring teams together to predict a fold from a sequence that has not yet been solved.结构生物信息学活动让各团队聚到一起，用尚未解出的序列预测折叠。

• Manuscripts are submitted through the publisher's online system and are assessed by independent referees before a decision.稿件通过出版方的在线系统投递，在作出决定之前由独立审稿人评估。

• The journal publishes a list of its editorial board, and the members work in universities and institutes across several continents.该刊公布其编委会名录，成员任职于数个大陆的高校与研究所。

• Authors are asked to make their coordinates and data available, so that a reported structure can be checked by others.作者被要求公开其坐标与数据，使所报结构可被他人检验。

• Open access is offered as an option beside the subscription route, and authors may pay to make a paper free at once.该刊在订阅路径之外提供开放获取选项，作者可付费让自己的论文即时免费。

• The journal states its expectations on authorship, on competing interests and on the handling of images in a published set of policies.该刊在公开的政策中写明对作者身份、利益冲突与图像处理的要求。

• Reviews and special issues are commissioned by the editors, and the board invites proposals for themes of its own.综述与专刊由编辑约稿，编委会也自行征集主题建议。

• The editorial office handles the submission process and answers queries from authors and referees by email.编辑部负责处理投稿流程，并以电子邮件答复作者与审稿人的查询。

• The journal keeps a close tie to the protein science community, and it reports on the results of shared benchmarking efforts.该刊与蛋白质科学界保持紧密联系，并报道共同基准测试的结果。