Journal of Pharmacokinetics and Pharmacodynamics

Journal of Pharmacokinetics and Pharmacodynamics is a Springer journal that traces its line to 1973 and covers pharmacometrics and related disciplines. It publishes theoretical and experimental work on drug disposition and action, and its 2025 impact factor is 3.3.《药代动力学与药效学杂志》是施普林格出版的期刊，其脉络可追溯到 1973 年，覆盖药理计量学及相关学科。该刊发表药物处置与作用的理论与实验研究，2025 年影响因子为 3.3。

Scope

• The journal covers all areas of pharmacometrics, since that is the discipline it serves.该刊覆盖药理计量学的各个领域，因为这是它所服务的学科。

• Pharmacokinetics is studied, and a paper may report how a drug moves through the body.药代动力学受到研究，论文可以报告药物如何在体内移动。

• Pharmacodynamics appears beside it, since the effect of a drug is the other half of the picture.药效学与之并列出现，因为药物的效应是这幅图的另一半。

• Population analysis is taken, and a study may model how a group of patients differs in its handling of a drug.群体分析会被接收，研究可以建模一组患者在处理药物上的差异。

• Physiologically based modelling is named, so a paper may build a model from the anatomy of an organ.基于生理的建模被列出，论文可以依据器官的解剖构建一个模型。

• Systems pharmacology is covered, since the effect of a therapy runs through many pathways at once.系统药理学也在覆盖之列，因为疗法的效应同时经由许多通路。

• Machine learning is applied to these questions, and the journal takes such work when the model is interpreted rather than left opaque.机器学习被应用于这些问题，该刊在模型被解读而非束之高阁时接收此类工作。

• Modelling and simulation methodology is studied, since a method is useful across many compounds.建模与仿真方法学受到研究，因为一种方法对许多化合物都有用。

• Clinical, experimental and theoretical papers are all taken.临床，实验与理论论文都会被接收。

• The disposition of a drug is examined, including its absorption and its elimination.药物的处置受到检视，包括其吸收与消除。

• The action of a drug is studied, since a concentration means little without the response it produces.药物的作用受到研究，因为离开它所引发的反应，浓度意义甚微。

• Application to drug development is taken, so a paper may inform how a candidate is advanced.在药物开发中的应用会被接收，论文可以为其候选物的推进提供依据。

• Application to clinical care is covered, since a dose must suit the patient in front of the prescriber.在临床照护中的应用也在覆盖之列，因为剂量必须适合处方者面前的这位患者。

• Precision medicine is named as an interest, and a study may link a characteristic of a patient to a suitable dose.精准医学被列为关注点，研究可以把患者的一项特征与合适的剂量相联系。

• A paper may report a model for the time course of a drug in a group of patients, and the account should show how the model was checked.论文可以报告药物在一组患者体内时间过程的模型，记述应说明该模型是如何被检验的。

• Work on the effect of a drug at its site of action is taken, since a concentration in the blood may not match one in the tissue.药物在其作用部位效应方面的工作会被接收，因为血中的浓度未必与组织中的相符。

• The journal covers the design of a study in this field, since a well-chosen sampling schedule tells more than a dense one.该刊覆盖该领域研究的设计，因为精心选择的采样时点比密集的采样更有信息。

• A study of a drug in children is taken, and the paper may set out how a dose should be scaled from adults.儿童用药的研究会被接收，论文可以提出剂量应如何自成人推算。

• Work on the interaction between two drugs is taken, since one may change how the other is cleared.两种药物相互作用方面的工作会被接收，因为一者可能改变另一者的清除方式。

• The journal takes work on a method that draws more from a small study, since a trial in a rare disease cannot enrol many.该刊接收能从小样本研究中获取更多信息的方法，因为罕见病的试验无法招募很多人。

• A paper may report a model of a biological pathway, and the journal asks that its parameters be judged against data.论文可以报告一条生物通路的模型，该刊要求其参数对照数据来评判。

• Work on the variability between patients is covered, since a dose that suits one may not suit another.患者间变异方面的工作也在覆盖之列，因为适合一人的剂量未必适合另一人。

• The journal takes work on the effect of a disease on drug handling, since a sick patient may clear a drug differently.该刊接收疾病对药物处置影响的工作，因为患病的患者对药物的清除可能不同。

• A paper may report the exposure of a drug and its relation to a response, which is the link the field looks for.论文可以报告药物的暴露及其与反应的关系，这是该领域所要寻找的联系。

• Work on the reporting of a model is taken, and the editors ask that the code and the data be made available.模型报告方面的工作会被接收，编辑要求把代码与数据公开可得。

• A paper may report a model built from data on many patients, and the account should show how well it predicts a group it did not see.论文可以报告依据许多患者数据构建的模型，记述应说明它对未见过的群体预测得如何。

• Work on the dose of a drug in an organ is taken, since the concentration at the target matters more than the one in the blood.药物在器官中剂量方面的工作会被接收，因为靶点的浓度比血中的更重要。

• The journal covers the choice of a sampling time, since a well-placed sample can replace many others.该刊覆盖采样时点的选择，因为一个位置恰当的样本可以替代许多其他样本。

• A study of a drug in an older group is taken, since the body handles a compound differently with age.年长群体用药的研究会被接收，因为身体处理化合物的方式随年龄而变。

• Work on the effect of food on absorption is taken, since a meal may change how much of a drug reaches the blood.食物对吸收影响方面的工作会被接收，因为一餐可能改变药物进入血液的量。

• The journal takes work on a model of a drug and its metabolite, since the two are linked by the chemistry of the body.该刊接收药物及其代谢物模型方面的工作，因为两者由体内的化学相连。

• A paper may report the variability of exposure between patients, and the journal asks how much of it a dose adjustment could remove.论文可以报告患者间暴露的变异，该刊追问剂量调整能消除其中多少。

• Work on the translation of a model to a clinic is taken, since a method is only useful if it changes a decision.模型向门诊转化方面的工作会被接收，因为一种方法只有在改变决策时才有用。

History

• The journal traces its line to 1973, when it began under another name.该刊的脉络可追溯到 1973 年，当时它以另一名称创办。

• It was issued first as the Journal of Pharmacokinetics and Biopharmaceutics.该刊最初以《药代动力学与生物药剂学杂志》之名出版。

• It took its present name in 2002, when its scope was restated.该刊于 2002 年改用现名，其范围也随之重述。

• It is published by Springer, from the house long known as Plenum.该刊由施普林格出版，出自长期以 Plenum 为人知的那家机构。

• The print number is 1567-567X and the electronic number 1573-8744.其印本刊号为 1567-567X，电子刊号为 1573-8744。

• Six issues appear in a year, so the title is bimonthly.该刊每年出版六期，因此为双月刊。

• Its impact factor was 2.745 for 2021 and 3.3 for 2025, with a five-year figure of 3.2.其影响因子 2021 年为 2.745，2025 年为 3.3，五年影响因子为 3.2。

• The title records a CiteScore of 5.1.该刊的 CiteScore 为 5.1。

• It is indexed in the Science Citation Index Expanded and in Scopus.该刊被科学引文索引扩展版与 Scopus 收录。

• Its record is also held by the national library of medicine.其记录也由美国国家医学图书馆保存。

• Publication runs on a hybrid model, so an author may choose the open access route.出版采用混合模式，因此作者可以选择开放获取路径。

• The journal promotes newer lines of work in the field, as its scope states.如该刊范围所述，它扶持该领域较新的工作路线。

Editors

• (Peter L. Bonate) is the editor-in-chief of the journal.（Peter L. Bonate）是该刊主编。

• He works in pharmacometrics, and he has published widely in the field.他从事药理计量学工作，并在该领域多有发表。

• The journal is edited for the publisher, and the editor works with a board that covers the discipline.该刊为出版方编辑，主编与一个覆盖该学科的编委会合作。

• A manuscript is sent to reviewers who work on the problem it addresses.稿件被送给研究其所处理问题的评审人。

• The editors receive the reports and take the decision on a paper.编辑收到报告后就论文作出决定。

• The board covers the several lines of work the journal publishes, so a paper is read by someone who knows its method.编委会覆盖该刊所发表的若干工作路线，因此论文由了解其方法的人审读。

• The journal office answers queries about submission and follows each paper.该刊办公室答复关于投稿的询问并跟踪每篇论文。

• Manuscripts are reviewed under a medical publishing code, and the journal states its policy on interests.稿件按医学出版规范评审，该刊声明其利益政策。

• The editors state that a paper is judged on whether it changes how a study is designed or a dose is chosen.编辑声明论文据其是否改变研究的设计或剂量的选择来评判。