Journal of General Physiology

The Journal of General Physiology is a monthly journal founded in 1918 and published by Rockefeller University Press in New York.《The Journal of General Physiology》是 1918 年创刊的月刊，由纽约的洛克菲勒大学出版社出版。

It publishes mechanistic and quantitative work on molecular and cellular physiology, with ion channels and membrane transport as its best-known territory.刊物发表分子与细胞生理学的机制性与定量研究，离子通道与膜转运是其最为人熟知的领域。

Its 2025 Journal Impact Factor is 3.2, with a five-year value of 3.3, and it ranks 27th among 89 journals in physiology.2025 年期刊影响因子为 3.2，五年影响因子为 3.3，在生理学 89 种期刊中排第 27 位。

Scope

• Ion channel gating is the journal's signature subject, covering voltage dependence, ligand activation, inactivation and modal behaviour.离子通道门控是该刊的标志性题目，涉及电压依赖性、配体激活、失活与模态行为。
• Permeation and selectivity are studied with electrophysiology, molecular dynamics and structural data brought together into one argument.通透与选择性研究把电生理、分子动力学与结构数据放进同一论证之中。
• Transporters and pumps appear through kinetics, stoichiometry and the coupling of ion movement to substrate translocation.转运体与泵通过动力学、化学计量以及离子移动与底物转运的偶联得到呈现。
• Membrane biophysics is treated seriously, including lipid-protein interactions, bilayer elasticity and the mechanical context of channel function.膜生物物理受到认真对待，包括脂质与蛋白的相互作用、双层弹性以及通道功能的力学环境。
• Excitation-contraction coupling in cardiac, skeletal and smooth muscle is a long-standing strand, from calcium release to myofilament activation.心脏、骨骼与平滑肌的兴奋-收缩偶联是长期主线，从钙释放延伸到肌丝激活。
• Calcium signalling papers follow sparks, waves and store-operated entry, often with quantitative imaging as the main method.钙信号论文追踪钙火花、钙波与钙库操纵性钙内流，常以定量成像为主要方法。
• Synaptic transmission and sensory transduction are covered at the level of release, receptor activation and adaptation.突触传递与感觉转导在释放、受体激活与适应的层面得到讨论。
• Intracellular signalling appears through second messengers, kinases and the local control of membrane excitability.细胞内信号通过第二信使、激酶以及对膜兴奋性的局部调控出现。
• Organelle physiology is part of the remit, with work on the endoplasmic reticulum, mitochondria, lysosomes and nuclear transport.细胞器生理属于收稿范围，涉及内质网、线粒体、溶酶体与核转运。
• Intracellular pH and ion homeostasis are studied as regulated variables rather than background conditions.细胞内 pH 与离子稳态被当作受调控的变量研究，而不是背景条件。
• Quantitative models and kinetic schemes are expected to be testable, and papers often pair a model with a discriminating experiment.定量模型与动力学方案须可检验，论文常把模型与具有判别力的实验配对。
• Single-molecule methods, spectroscopy and fluorescence approaches are published when they resolve a physiological question.单分子方法、光谱与荧光手段在能够解决生理学问题时被发表。
• Patch clamp, voltage clamp and perforated-patch recordings remain the core techniques, and methodological rigour is judged closely.膜片钳、电压钳与穿孔膜片记录仍是核心技术，方法学的严谨程度受到仔细评判。
• Structure-function work connects cryo-electron microscopy and crystallography to functional measurements rather than standing alone.结构与功能研究把冷冻电镜和晶体学与功能测量相连，而不是孤立呈现结构。
• Papers are expected to offer mechanistic insight, and a descriptive catalogue of conditions is not usually enough for acceptance.刊物要求论文提供机制性洞见，单纯罗列条件的描述性工作通常不足以被接受。
• The editors work across cell types, from neurons and photoreceptors to cardiac myocytes, epithelia and immune cells.编辑关注的细胞类型从神经元、光感受器到心肌细胞、上皮与免疫细胞。

History

• The journal was founded in 1918 by Jacques Loeb, then a member of the Rockefeller Institute for Medical Research.该刊于 1918 年由 Jacques Loeb 创办，他当时是洛克菲勒医学研究所的成员。
• Winthrop Osterhout of Harvard University shared the early editing duties with Loeb, and the two set the journal's physical-chemical tone.哈佛大学的 Winthrop Osterhout 与 Loeb 分担早期编辑工作，两人奠定了刊物的物理化学取向。
• The founding announcement argued that physiology had drifted toward applied work and that general physiology needed a journal of its own.创刊公告认为生理学已偏向应用，普通生理学需要一份自己的刊物。
• It began as a bimonthly and became monthly in 1966, when Paul Cranefield took over the editorship.刊物起初为双月刊，1966 年 Paul Cranefield 接任主编后改为月刊。
• From 1968 to 1984 Cranefield edited alone, supported by honorary editors and an editorial board.1968 年至 1984 年间，Cranefield 在名誉编辑与编委会的支持下独自主持编辑工作。
• Associate editors were appointed in 1984, and the weekly editors' meeting became the standard way of choosing reviewers and weighing reviews.1984 年起设立副编辑，每周编辑会议成为挑选审稿人与权衡审稿意见的固定方式。
• Olaf S. Andersen succeeded Cranefield in 1995, Edward N. Pugh Jr. followed in 2008 and Sharona E. Gordon in 2014.Olaf S. Andersen 于 1995 年接替 Cranefield，Edward N. Pugh Jr. 于 2008 年、Sharona E. Gordon 于 2014 年相继接任。
• David Eisner of the University of Manchester, a cardiac physiologist, is the current editor-in-chief.曼彻斯特大学的心脏生理学家 David Eisner 是现任主编。
• Full-text HTML appeared online in 1997, and the archive has been free from six months after publication back to the 1918 issue.全文 HTML 于 1997 年上线，从出版后六个月起直至 1918 年创刊号的内容一直免费。
• The complete archive is deposited in PubMed Central, and since 2008 authors have retained copyright under a Creative Commons licence.全部过刊存放于 PubMed Central，自 2008 年起作者在知识共享许可下保留著作权。
• Articles are posted online twice a month even though the printed issue remains monthly, and the median time from acceptance to publication is 31 days.尽管印刷版仍为月刊，文章每月两次在线发布，从录用到出版的中位时间为 31 天。
• Impact factors ran at 4.086 in 2021, 4.0 in 2022, 3.3 in 2023, 2.9 in 2024 and 3.2 in 2025.影响因子在 2021 年为 4.086，2022 年为 4.0，2023 年为 3.3，2024 年为 2.9，2025 年为 3.2。
• The 2025 report counted 6,902 citations to the journal, 51 articles and 56 citable items.2025 年报告统计该刊被引 6902 次，论文 51 篇，可引用条目 56 项。
• About 32 percent of recent content is gold open access, and the title is indexed in MEDLINE, PubMed Central and Science Citation Index Expanded.近期内容约有 32% 为金色开放获取，刊物被 MEDLINE、PubMed Central 与科学引文索引扩展版收录。

Editors

• David Eisner, professor of cardiac physiology at Manchester, has worked on intracellular sodium and calcium regulation and on arrhythmia mechanisms.曼彻斯特大学心脏生理学教授 David Eisner 研究细胞内钠与钙的调节以及心律失常机制。
• Associate editors are assigned to broad subfields, and the weekly meeting lets them compare notes on manuscripts that sit between fields.副编辑按大的子领域分工，每周会议让彼此就跨领域的稿件交换判断。
• Richard W. Aldrich of the University of Texas at Austin, a student of channel gating and calcium signalling, has served as an associate editor.得克萨斯大学奥斯汀分校的 Richard W. Aldrich 研究通道门控与钙信号，曾任副编辑。
• Henk Granzier of the University of Arizona, known for work on titin and myofilament mechanics, has also served as an associate editor.亚利桑那大学的 Henk Granzier 以肌联蛋白与肌丝力学研究知名，也曾任副编辑。
• Merritt Maduke of Stanford University, who studies CLC channels and transporters, and Eduardo Rios of Rush University, who works on calcium release, appear on the editorial roster.研究 CLC 通道与转运体的斯坦福大学 Merritt Maduke，以及研究钙释放的拉什大学 Eduardo Rios，都在编辑名单之中。
• Olaf Andersen of Weill Cornell Medical College edits the Perspectives series and writes on lipid bilayers and channel energetics.威尔康奈尔医学院的 Olaf Andersen 主持展望栏目，并研究脂质双层与通道能量学。
• The editorial advisory board includes Frances Ashcroft of Oxford, Bruce Bean of Harvard and Baron Chanda of Washington University in St. Louis.编辑顾问委员会包括牛津大学的 Frances Ashcroft、哈佛大学的 Bruce Bean 与圣路易斯华盛顿大学的 Baron Chanda。
• Further advisers come from Weill Cornell, Vanderbilt, Case Western Reserve, Peking University and Semmelweis University, among other institutions.其他顾问来自威尔康奈尔、范德堡、凯斯西储、北京大学与塞梅尔魏斯大学等机构。
• A managing editor runs the office, and production staff handle figure preflight and image screening before an article is released.专职主编管理编辑部，制作人员在文章发布前负责图件预检与图像筛查。
• Reviewers are chosen by subfield competence, and the editors read the reports together before a decision is reached.审稿人按子领域专长挑选，编辑在作出决定前共同阅读审稿意见。