DNA Repair

本刊是 2002 年创立的同行评审期刊，由 Elsevier 出版，前身是《Mutation Research》的 DNA 修复分辑。

刊物覆盖 DNA 修复、诱变、细胞周期调控、凋亡以及细胞对基因组损伤的其他生物学反应，并关注这些过程与人类疾病的关系。

2025 年影响因子为 3.2，五年影响因子为 3.6，在遗传学 192 种期刊中列第 72 位，在毒理学 106 种期刊中列第 49 位，均处于第二四分位。

Scope

• DNA Repair covers genetic, cellular, biochemical, structural and molecular aspects of DNA repair and the cellular response to DNA damage.《DNA Repair》覆盖 DNA 修复与细胞 DNA 损伤应答的遗传、细胞、生化、结构与分子层面。
• Base excision repair, nucleotide excision repair and mismatch repair are treated as core pathways.碱基切除修复、核苷酸切除修复与错配修复被视为核心通路。
• Double-strand break repair is studied through homologous recombination and non-homologous end joining.双链断裂修复通过同源重组与非同源末端连接加以研究。
• Translesion synthesis, replication stress and the tolerance of damaged templates receive attention.跨损伤合成、复制压力以及对受损模板的耐受受到关注。
• DNA damage signalling kinases, checkpoint control and cell cycle regulation are central themes.DNA 损伤信号激酶、检查点控制与细胞周期调控是核心主题。
• Apoptosis and other cell fate decisions after genomic insult are examined alongside repair itself.基因组损伤后的凋亡及其他细胞命运决定与修复过程一并考察。
• Epigenetics and chromatin structure are studied as modulators of repair accessibility and outcome.表观遗传与染色质结构被作为修复可及性与结局的调节因素加以研究。
• Genome stability, genome maintenance and the avoidance of mutation are recurring concerns.基因组稳定性、基因组维护以及突变规避是反复出现的关切。
• Mutagenesis and signature mutations are analysed to trace exposures and repair defects.诱变与特征性突变被用于追溯暴露史与修复缺陷。
• Genomics and bioinformatics approaches support pathway discovery and the interpretation of repair defects.基因组学与生物信息学方法支撑通路发现和修复缺陷的解读。
• Human disease papers address ageing, cancer and neurological dysfunction linked to defective repair.人类疾病论文讨论与修复缺陷相关的衰老、癌症与神经功能障碍。
• Immune responses and inflammation triggered by damaged DNA or by repair intermediates are within scope.受损 DNA 或修复中间产物引发的免疫反应与炎症属于收稿范围。
• Structural biology and computational modelling of repair proteins and complexes are welcomed.修复蛋白与复合物的结构生物学及计算建模受到欢迎。
• Mitochondrial DNA repair and the maintenance of organelle genomes are considered.线粒体 DNA 修复与细胞器基因组的维护也在考虑之列。
• Repair in stem cells, development and tissue homeostasis is studied for its role in disease.干细胞、发育与组织稳态中的修复因其在疾病中的作用而受到研究。
• Therapeutic targeting of repair, including synthetic lethality and chemo-radiosensitisation, is covered.修复通路的治疗性干预，包括合成致死与放化疗增敏，均在覆盖之内。
• Environmental and occupational genotoxic exposures are examined through repair capacity and biomarkers.环境与职业基因毒性暴露通过修复能力与生物标志物加以考察。
• Genome editing and the repair of engineered breaks connect the journal to applied genetics.基因组编辑与人工断裂的修复把刊物与应用遗传学连接起来。
• Model organisms from bacteria and yeast to mice support mechanistic comparisons across species.从细菌、酵母到小鼠的模式生物支撑跨物种的机制比较。
• Databases, methods and new technologies that support repair research are explicitly invited.支撑修复研究的数据库、方法与新技术被明确邀请投稿。
• Full-length research articles, brief reports and reviews form the main article types.全文研究论文、研究简报与综述构成主要稿件类型。
• Letters to the editor, hot topics, classics in DNA repair, historical reflections, book reviews and meeting reports are also considered.致编辑来信、热点话题、DNA 修复经典、历史回顾、书评与会议报告也在考虑之列。

History

• Mutation Research began in May 1964 and later grew into a set of separately titled sections.《Mutation Research》于 1964 年 5 月创刊，后来发展为若干独立命名的分辑。
• A DNA repair section appeared within Mutation Research from 1973, using the parent volume numbering.DNA 修复分辑自 1973 年起出现在《Mutation Research》中，沿用母刊的卷号。
• From March 1989 the section was numbered separately, starting with volume 217, number 2.自 1989 年 3 月起该分辑独立编号，起始于第 217 卷第 2 期。
• The section closed with volume 487, numbers 3 and 4, in December 2001.该分辑以 2001 年 12 月的第 487 卷第 3 至 4 期结束。
• DNA Repair was relaunched as an independent journal with volume 1, number 1, on 22 January 2002.《DNA Repair》于 2002 年 1 月 22 日以独立刊物的第 1 卷第 1 期重新创刊。
• Errol Friedberg introduced the relaunch as a new journal format in the opening editorial.Errol Friedberg 在开篇社论中把这次重启介绍为一种新的刊物形态。^[1]
• Samuel H. Wilson has served as editor-in-chief since the relaunch, with Friedberg and Philip Hanawalt later named editors emeritus.Samuel H. Wilson 自创刊起担任主编，Friedberg 与 Philip Hanawalt 后来被授予荣休编辑称号。
• The journal is published monthly by Elsevier from Amsterdam and follows a hybrid open access model.刊物由 Elsevier 在阿姆斯特丹按月出版，采用混合开放获取模式。
• The article processing charge is 3390 US dollars, and about 40 per cent of recent articles are open access.文章处理费为 3390 美元，近年约四成论文以开放获取形式发表。
• Impact factors moved from 4.913 in 2021 and 4.354 in 2022 to 3.0 in 2023, 2.7 in 2024 and 3.2 in 2025.影响因子从 2021 年的 4.913、2022 年的 4.354 降至 2023 年的 3.0 与 2024 年的 2.7，2025 年回升至 3.2。
• The 2025 window recorded 6424 citations to 93 articles, with 93 citable items.2025 年统计窗口记录 6424 次引用，施引对象为 93 篇论文，可被引条目 93 项。
• The journal is indexed in MEDLINE and PubMed, Science Citation Index Expanded and Scopus.刊物被 MEDLINE 与 PubMed、科学引文索引扩展版以及 Scopus 收录。
• It ranks 72 of 192 in Genetics and Heredity and 49 of 106 in Toxicology for 2025, both in the second quartile.2025 年刊物在遗传学 192 种期刊中列第 72 位，在毒理学 106 种期刊中列第 49 位，均处第二四分位。

Editors

• Samuel H. Wilson, based in Chapel Hill, North Carolina, leads the journal and works on base excision repair and DNA polymerase beta.常驻北卡罗来纳州教堂山的 Samuel H. Wilson 领导刊物，研究碱基切除修复与 DNA 聚合酶 β。
• Errol C. Friedberg and Philip C. Hanawalt are editors emeritus and represent the founding generation of repair research.Errol C. Friedberg 与 Philip C. Hanawalt 任荣休编辑，代表修复研究的创始一代。
• Penny A. Jeggo of the University of Sussex is annual reviews editor, covering the DNA double-strand break response.萨塞克斯大学的 Penny A. Jeggo 任年度综述编辑，负责 DNA 双链断裂应答方向。
• Keith W. Caldecott, also at Sussex, is an associate editor for ageing, mitosis, neurodegeneration and proteomics.同样任职于萨塞克斯大学的 Keith W. Caldecott 是副编辑，负责衰老、有丝分裂、神经退行与蛋白质组学。
• Jessica A. Downs of the Institute of Cancer Research covers epigenetics and genome stability.英国癌症研究所的 Jessica A. Downs 负责表观遗传与基因组稳定性。
• Martin Gellert of the National Institutes of Health works on V(D)J recombination, topoisomerase and non-homologous end joining.美国国立卫生研究院的 Martin Gellert 研究 V(D)J 重排、拓扑异构酶与非同源末端连接。
• Sue Jinks-Robertson of Duke University covers homologous recombination, transcription and genome stability.杜克大学的 Sue Jinks-Robertson 负责同源重组、转录与基因组稳定性。
• Alan R. Lehmann at Sussex brings xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy expertise.萨塞克斯大学的 Alan R. Lehmann 带来着色性干皮病、科凯恩综合征与毛发硫营养不良方面的专长。
• Guo-Min Li at the University of Texas Southwestern covers mismatch repair, genome instability and cancer.德克萨斯大学西南医学中心的 Guo-Min Li 负责错配修复、基因组不稳定与癌症。
• Jeffrey H. Miller at the University of California, Los Angeles, works on mutation and DNA repair.加州大学洛杉矶分校的 Jeffrey H. Miller 研究突变与 DNA 修复。
• Marco Muzi Falconi of the University of Milan covers genome integrity and DNA damage checkpoints.米兰大学的 Marco Muzi Falconi 负责基因组完整性与 DNA 损伤检查点。
• Leona D. Samson at the Massachusetts Institute of Technology works on toxigenomics and animal models of repair.麻省理工学院的 Leona D. Samson 研究毒物基因组学与修复动物模型。
• Robert W. Sobol at the University of South Alabama covers base excision repair, ADP-ribose and NAD+ metabolism.南阿拉巴马大学的 Robert W. Sobol 负责碱基切除修复、ADP-核糖与 NAD+ 代谢。
• Shunichi Takeda of Kyoto University brings reverse genetics and radiation genetics to the board.京都大学的 Shunichi Takeda 为编委会带来反向遗传学与辐射遗传学。
• Bennett Van Houten at the University of Pittsburgh covers repair, drug discovery and redox pharmacology.匹兹堡大学的 Bennett Van Houten 负责修复、药物发现与氧化还原药理学。
• Niels de Wind at Leiden University Medical Centre covers DNA damage responses and translesion synthesis.莱顿大学医学中心的 Niels de Wind 负责 DNA 损伤应答与跨损伤合成。
• Roger Woodgate at the National Institutes of Health covers replication, repair and mutagenesis in prokaryotes and eukaryotes.美国国立卫生研究院的 Roger Woodgate 负责原核与真核生物的复制、修复与诱变。
• The wider editorial board adds expertise in chromatin, cancer pharmacology, radiation oncology and genetic toxicology.更广泛的编委会补充染色质、癌症药理学、放射肿瘤学与遗传毒理学方面的专长。
• The annual reviews editor commissions and organises the journal's review content each year.年度综述编辑每年策划并组织刊物的综述内容。
• Manuscripts are submitted through Editorial Manager and assigned to the editor whose expertise matches the pathway studied.稿件经 Editorial Manager 提交，并按所研究的修复通路分派给相应编辑。