Critical Reviews in Biochemistry and Molecular Biology

《生物化学与分子生物学关键评论》（Critical Reviews in Biochemistry and Molecular Biology，标准缩写为 Crit. Rev. Biochem. Mol. Biol.）是一本经同行评审的权威国际综述性学术期刊，由泰勒-弗朗西斯出版集团（Taylor & Francis）出版，专注于发表生物化学、分子生物学及相关前沿交叉学科的批判性长篇综述。Critical Reviews in Biochemistry and Molecular Biology (standard abbreviation: Crit. Rev. Biochem. Mol. Biol.) is a peer-reviewed, authoritative international review journal published by Taylor & Francis, focusing on comprehensive, critical reviews across biochemistry, molecular biology, and related frontier interdisciplinary fields.

Scope

期刊旨在对生物化学、生物物理学和分子生物学各个核心领域的最新突破与复杂争议问题提供权威、全面且深入的批判性评述。The journal aims to provide authoritative, comprehensive, and in-depth critical evaluations of recent breakthroughs and complex controversies across all core areas of biochemistry, biophysics, and molecular biology. 其收稿范围主要涵盖：Its scope primarily encompasses:

• 染色质结构、表观遗传学与转录调控： 组蛋白修饰机制、染色质重塑复合物、非编码 RNA 的生物学功能及基因表达调控网络。Chromatin structure, epigenetics, and transcriptional regulation: Mechanisms of histone modifications, chromatin remodeling complexes, biological functions of non-coding RNAs, and gene regulatory networks.
• DNA 复制、损伤修复与重组： 维持基因组稳定性的分子机制及其与衰老、肿瘤发生的关联。DNA replication, damage repair, and recombination: Molecular mechanisms maintaining genome stability and their links to aging and tumorigenesis.
• 蛋白质与大分子机器结构生物学： 蛋白质折叠机制、泛素-蛋白酶体降解途径、相分离现象，以及核糖体、剪接体等超大分子复合体的构象与动力学特征。Structural biology of proteins and macromolecular machines: Mechanisms of protein folding, ubiquitin-proteasome degradation pathways, phase separation phenomena, and conformational and dynamic properties of megadalton complexes such as ribosomes and spliceosomes.
• 细胞信号转导与代谢重构： 跨膜信号传递网络、脂质与糖代谢调控、细胞自噬以及细胞命运决定的生化基础。Cellular signal transduction and metabolic rewiring: Transmembrane signaling networks, regulation of lipid and carbohydrate metabolism, autophagy, and the biochemical foundations governing cell fate decisions.
• 前沿生化技术与定量分子生物学： 冷冻电镜（Cryo-EM）、单分子荧光技术、定量蛋白质组学及高通量基因编辑在机制研究中的应用。Frontier biochemical technologies and quantitative molecular biology: Applications of cryogenic electron microscopy (cryo-EM), single-molecule fluorescence, quantitative proteomics, and high-throughput gene editing in mechanistic investigations.

与常规文献综述不同，该刊强调“批判性”（Critical），要求作者不仅客观汇总已发表的研究成果，更需指出领域内的实验局限、数据矛盾、尚未解决的核心假说，并提出指导未来研究方向的概念性模型。Distinct from routine literature summaries, the journal emphasizes a "critical" perspective, requiring authors not only to objectively synthesize published findings, but also to identify experimental limitations, data discrepancies, and unresolved core hypotheses, while proposing conceptual models to guide future research directions. 期刊文章多为编辑特邀或作者提交预审方案（Pre-submission proposal）获批后撰写。Articles are predominantly commissioned by the editors or invited following the approval of pre-submission proposals.

History

• 创立与原刊名（1972年）： 期刊于1972年创刊，最初由 CRC Press 创办并发行，原定刊名为 CRC Critical Reviews in Biochemistry，旨在系统梳理当时正处于飞速发展期的现代生物化学理论体系。Founding and original title (1972): The journal was established in 1972 and initially published by CRC Press under the title CRC Critical Reviews in Biochemistry, aiming to systematically survey the theoretical frameworks of modern biochemistry during a period of rapid expansion.
• 扩展与更名（1989年）： 随着重组 DNA 技术、分子克隆与基因表达调控等分子生物学理论的全面成熟，为准确反映期刊对微观生物学机制与分子水平研究的延伸，期刊于1989年自第24卷起正式更名为现刊名 Critical Reviews in Biochemistry and Molecular BiologyInforma Healthcare / Taylor & Francis. Critical Reviews in Biochemistry and Molecular Biology: Aims & Scope. https://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ibmg20(https://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ibmg20)。Expansion and renaming (1989): Following the maturation of molecular biology—including recombinant DNA technology, molecular cloning, and transcriptional regulation—the journal was officially renamed to its current title, Critical Reviews in Biochemistry and Molecular Biology, starting with Volume 24 in 1989 to reflect its expanded coverage of microscopic mechanisms and molecular-level researchInforma Healthcare / Taylor & Francis. Critical Reviews in Biochemistry and Molecular Biology: Aims & Scope. https://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ibmg20(https://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ibmg20).
• 出版机构沿革与数字化： CRC Press 的期刊出版业务后归入 Informa 旗下，并由 Taylor & Francis 统一运营管理。Publishing history and digitization: The journal publishing division of CRC Press was later acquired by Informa and operated under the Taylor & Francis portfolio. 进入21世纪后，期刊由印刷版主导全面转为数字化连续出版，维持双月刊发行周期，并长期处于生物化学与分子生物学领域综述期刊的影响因子前列。In the 21st century, the journal transitioned from print-dominated dissemination to digital continuous publishing, maintaining a bimonthly publication schedule and consistently ranking among the leading review journals by impact factor in biochemistry and molecular biology.

Editors

期刊实行严格的编辑同行评审责任制，历任主编多为在结构生物学与生物化学领域享有盛誉的国际资深学者：The journal maintains a rigorous editorial peer-review system, with its successive editors-in-chief being distinguished international scholars in structural biology and biochemistry:

• 创刊与早期主编： 杰拉尔德·法斯曼（Gerald D. Fasman，布兰代斯大学教授），作为生物物理化学与蛋白质构象预测领域的知名学者，他长期领导该刊确立了严谨的学术定位。Founding and early Editor-in-Chief: Gerald D. Fasman (Professor at Brandeis University), a renowned scholar in biophysical chemistry and protein secondary structure prediction, who guided the journal over many years to establish its rigorous scholarly standards.
• 长期主编（1998–2020年）： 迈克尔·布斯特（Michael Bustin，美国国立卫生研究院国家癌症研究所（NIH/NCI）资深研究员），染色质生物学与非组蛋白染色体蛋白结构功能研究的权威科学家，其任内极大拓展了期刊在表观遗传学与染色质领域的学术影响力。Long-serving Editor-in-Chief (1998–2020): Michael Bustin (Senior Investigator at the National Cancer Institute, National Institutes of Health [NIH/NCI]), a leading authority on chromatin biology and the structure and function of non-histone chromosomal proteins, whose tenure substantially expanded the journal's impact across epigenetics and chromatin dynamics.
• 近期与现任主编： 保罗·考夫曼（Paul D. Kaufman，马萨诸塞大学陈医学院分子、细胞与癌症生物学系教授），主要研究方向为染色质组装、DNA 复制偶联核小体沉积机制及基因组稳定性Taylor & Francis Online. Editorial Board: Critical Reviews in Biochemistry and Molecular Biology. https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=ibmg20(https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=ibmg20)。Recent and current Editor-in-Chief: Paul D. Kaufman (Professor in the Department of Molecular, Cell and Cancer Biology at UMass Chan Medical School), whose research centers on chromatin assembly, DNA replication-coupled nucleosome assembly mechanisms, and genome stabilityTaylor & Francis Online. Editorial Board: Critical Reviews in Biochemistry and Molecular Biology. https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=ibmg20(https://www.tandfonline.com/action/journalInformation?show=editorialBoard&journalCode=ibmg20).