Comprehensive Physiology

Comprehensive Physiology (Compr. Physiol.) is a physiology journal published by Wiley on behalf of the American Physiological Society. Founded in January 2011, it grew out of the digitisation of the society's Handbook of Physiology, was refocused on interorgan communication in 2025, appears bimonthly, and had a 2025 impact factor of 6.3.《综合生理学》（Comprehensive Physiology''''，缩写 Compr. Physiol.''）是约翰威立代表美国生理学会出版的生理学刊物，2011 年 1 月创刊。该刊源于该会《生理学手册》的数字化工程，2025 年改版后聚焦器官间通讯，现为双月刊，二〇二五年影响因子为 6.3。

Scope

The journal's editorial stance is that physiology should be written as authoritative reviews capable of long-term revision: however specialised the topic, a paper has to give a systematic, citable and continually updatable account of a physiological question. Since the 2025 refocus, coverage is organised around interorgan communication and concentrates on:本刊的取稿立场是「把生理学写成可长期修订的权威综述」：一篇稿件不论题目多么专门，都要对某一生理议题给出系统、可引用、可持续更新的完整叙述。2025 年改版后收文围绕器官间通讯组织，重点包括：

• Interorgan cellular communication: signalling between organs, endocrine and paracrine communication, the role of organ crosstalk in homeostasis, and communication failure in disease.器官间细胞通讯： 器官之间的信号传递、远距与旁分泌通讯、器官对话在稳态中的角色、通讯失衡与疾病。

• Molecular and cellular mechanisms: signalling pathways and receptors, transport and channels, metabolic and energy sensing, and the molecular basis of cellular response.分子与细胞机制： 信号通路与受体、转运与通道、代谢与能量感应、细胞应答的分子基础。

• Signalling mediators: cytokines, hormones and neurotransmitters, extracellular vesicles and exosomes, metabolites as signalling molecules, and gaseous messenger molecules.信号介质： 细胞因子、激素与神经递质、胞外囊泡与外泌体、代谢物作为信号分子、气体信使分子。

• Systems biology and modelling: modelling of interorgan communication networks, multiscale integration, quantitative description of physiological systems, and computational models and simulation.系统生物学与建模： 器官通讯网络建模、多尺度整合、生理系统的定量描述、计算模型与仿真。

• Pathology and pathogenesis: disease arising from disordered interorgan communication, metabolic syndrome and endocrine disturbance, systemic effects of organ failure, and compensation and decompensation.病理与发病机制： 器官间通讯异常导致的疾病、代谢综合征与内分泌紊乱、器官衰竭的系统性影响、代偿与失代偿。

• Methods and technology: physiological measurement and imaging, omics and single-cell methods, animal models and human studies, and data analysis and reproducibility.方法与技术： 生理学测量与成像技术、组学与单细胞方法、动物模型与人体研究、数据分析与可重复性。

The journal has been fully gold open access since the refocus, with an article processing charge of 3,750 US dollars. The publisher reports an acceptance rate of 42 per cent, eleven days to first decision, 85 days to acceptance and thirteen days from acceptance to publication, the first-decision figure including editorial screening.本刊自改版起为完全金色开放获取，文章处理费为三千七百五十美元；出版方公布录用比例为百分之四十二、投稿至首次决定十一天、投稿至接收八十五天、接收至出版十三天，其中首次决定包含编辑部初筛。^[1]

History

• Founding (2011): the first issue appeared in January 2011 with Ronald L. Terjung as founding editor. The rationale was to digitise and keep up to date the more than thirty thousand pages of the society's Handbook of Physiology.创刊（2011年）： 2011 年 1 月出版首期，首任主编为（Ronald L. Terjung）；创刊动因是把美国生理学会《生理学手册》三万余页的经典内容数字化并持续更新。^[2]

• Refocus (2025): in October 2024 the American Physiological Society and Wiley announced a refocus of the journal on interorgan communication. The first issue under the new remit appeared in January 2025 and the journal moved to bimonthly publication, six issues a year, from February.改版（2025年）： 2024 年 10 月美国生理学会与约翰威立宣布改版，本刊转为聚焦器官间通讯；2025 年 1 月上线改版后的首期，2 月起改为双月刊，每年六期。^[3]

• Metrics and indexing: the impact factor is 6.3, the CiteScore 8.6 and the journal citation indicator 2.23, all official 2025 figures from the publisher. The journal is indexed in the Science Citation Index Expanded and Scopus指标与收录： 影响因子 6.3、引用分数 8.6、期刊引文指标 2.23，均为出版方官方 2025 年数值；本刊被科学引文索引扩展版与 Scopus 收录，出版方指标页未标注 MEDLINE；另有来源列 2024 年影响因子 5.2，与官方口径不同。 the publisher's metrics page does not indicate MEDLINE. Another source gives a 2024 impact factor of 5.2, which differs from the official basis.

Editors

The journal has had only two editors since founding, both appointed by the American Physiological Society. The present editor comes from the University of Illinois Chicago, was appointed in 2024 and took up the post in 2025, overseeing the refocus.本刊创刊以来仅两任主编，均由美国生理学会任命；现任主编来自伊利诺伊大学芝加哥分校，2024 年获任命并于 2025 年上任，主持改版工作。^[3]

• Present editor-in-chief: J. Usha Raj is the Anjuli S. Nayak Professor of Pediatrics at the University of Illinois Chicago, appointed in 2024 and taking up the post in 2025.现任主编： （J. Usha Raj）供职于伊利诺伊大学芝加哥分校儿科，为（Anjuli S. Nayak）讲席教授，2024 年任命、2025 年上任。

• Founding editor: Ronald L. Terjung was the founding editor, serving from 2011 to 2024 at the University of Missouri and overseeing the digitisation and adaptation of the Handbook of Physiology content.首任主编： （Ronald L. Terjung）任首任主编，2011 年至 2024 年在任，供职于密苏里大学，主持了《生理学手册》内容的数字化与改编工作。

• Role in the field: the journal is an unusual handbook-format title in physiology, and its long reviews are widely used in teaching and cited in research. The society has also published Physiological Reports with Wiley since 2013 to carry primary research.学科角色： 本刊是生理学领域少见的「手册型」刊物，其长篇综述被广泛用于教学与研究引用；该会自 2013 年起另与约翰威立合作出版《生理学报告》分担原始研究。^[4]