Chemico-Biological Interactions

Chemico-Biological Interactions (Chem.-Biol. Interact.) is a toxicology journal published by Elsevier. Founded in October 1969, it concentrates on the mechanisms by which chemical substances interact with biological systems, appears eighteen times a year, and had a 2025 impact factor of 5.2.《化学—生物学相互作用》（Chemico-Biological Interactions''''，缩写 Chem.-Biol. Interact.''）是爱思唯尔出版的毒理学刊物，1969 年 10 月创刊。该刊以化学物质与生物系统相互作用的机制研究为主，现为每年十八期，二〇二五年影响因子为 5.2。

Scope

The journal's editorial stance is that mechanism is required: however complete the exposure data, a paper must give a mechanistic account of how a chemical interacts with a biological system. The editorial office explicitly declines purely descriptive studies and papers on plant extracts or herbal preparations that lack chemical characterisation. Coverage runs across mechanistic toxicology and concentrates on:本刊的取稿立场是「必须有机制」：一篇论文不论暴露数据多么完整，都要给出化学物质与生物系统相互作用的机制解释；编辑部明确拒收纯描述性研究，以及未作化学表征的植物提取物与草药类论文。收文覆盖毒理学的机制方向，重点包括：

• Mechanisms of interaction: metabolic activation and detoxication of xenobiotics, covalent binding and adduct formation, oxidative stress and antioxidant defence, and perturbation of cell signalling.相互作用的毒理机制： 外源物的代谢活化与解毒、共价结合与加合物形成、氧化应激与抗氧化防御、细胞信号通路扰动。

• Carcinogenesis: genotoxic and non-genotoxic mechanisms, DNA damage and repair, epigenetic alteration, and tumour promotion and progression.致癌作用： 遗传毒性与非遗传毒性致癌机制、DNA 损伤与修复、表观遗传改变、肿瘤促进与演进。

• Mutagenesis: gene mutation and chromosomal aberration, mutagenicity testing and evaluation, biomarkers of genetic damage, and species differences and extrapolation.致突变： 基因突变与染色体畸变、致突变试验与评价方法、遗传损伤的生物标志物、种属差异与外推。

• Respiratory toxicology: inhaled particles and fibres, airway and alveolar injury, mechanisms of fibrosis and pneumoconiosis, and toxicology of air pollutants.呼吸毒理： 吸入性颗粒物与纤维、气道与肺泡损伤、尘肺与纤维化机制、空气污染物毒理。

• Neurotoxicology and reproductive and developmental toxicology: neurotoxicants and developmental neurotoxicity, reproductive toxicity and embryogenesis, endocrine disruption, and transgenerational effects.神经毒理与生殖发育毒理： 神经毒物与神经发育损伤、生殖毒性与胚胎发育、内分泌干扰、跨代效应。

• Immunotoxicology: immunosuppression and immunostimulation, hypersensitivity and autoimmunity, effects of chemicals on immune cells, and methods for immunotoxicological assessment.免疫毒理： 免疫抑制与免疫刺激、超敏反应与自身免疫、化学物对免疫细胞的作用、免疫毒理的评价方法。

The journal is hybrid and the gold open access article processing charge is 3,580 US dollars. The publisher reports seven days to first decision, thirty-seven days to a decision after review and 96 days to acceptance, the first-decision figure including editorial screening本刊为混合出版，金色开放获取的文章处理费为三千五百八十美元；出版方公布投稿至首次决定七天、复审后决定三十七天、投稿至接收九十六天，其中首次决定包含编辑部初筛，录用比例未公布。 no acceptance rate is published.^[1]

History

• Founding (1969): volume 1, issue 1 appeared in October 1969 with the place of publication given as Amsterdam. Neither the publisher nor the NLM catalogue records a founder or a founding rationale.创刊（1969年）： 1969 年 10 月出版第 1 卷第 1 期，创刊时出版地设于阿姆斯特丹；创刊人与创刊动因出版方未予记载，NLM 目录中亦无相关记录。^[2]

• Title and publishing history: the journal has used its present name since founding, with no predecessor title and no renaming, so the founding year is also the year the present name took effect. The place of publication was Amsterdam in the early years and is now registered as Limerick.刊名与出版沿革： 本刊自创刊起即用现名，无前身刊名、亦无改名，创刊年即现名启用年；出版地在早期为阿姆斯特丹，现登记为爱尔兰利默里克。

• Frequency and metrics: the journal appears eighteen times a year. The impact factor is 5.2 and the CiteScore 10.3, the two figures agreeing across the publisher's own page, and the journal is indexed in the Science Citation Index Expanded, Scopus and MEDLINE.刊期与指标： 本刊现为每年十八期；影响因子 5.2、引用分数 10.3，两项数值在出版方官网同一页面上一致；被科学引文索引扩展版、Scopus 与 MEDLINE 收录。^[1]

Editors

The present editor-in-chief comes from the human and environmental toxicology group at the University of Konstanz in Germany. The publisher's site publishes no list of past editors, so neither the previous editors nor the founding editor can be established from official sources.本刊现任主编来自德国康斯坦茨大学的人类与环境毒理学团队；出版方官网未公布历任主编名录，因此该刊的历任主编与首任主编均无官方依据。^[3]

• Present editor-in-chief: Daniel R. Dietrich of the human and environmental toxicology group at the University of Konstanz works on toxicological mechanisms and in vitro methods. The publisher does not state the year of appointment.现任主编： （Daniel R. Dietrich）供职于康斯坦茨大学人类与环境毒理学组，研究方向为毒理机制与体外方法；出版方未公布其就任年份。

• Role in the field: the journal is a long-standing venue for mechanistic toxicology. Its explicit exclusion of purely descriptive work and of botanicals without chemical characterisation is unusual among European toxicology titles, and it has long served as a channel for research on chemical carcinogenesis and mutagenesis.学科角色： 本刊是机制毒理学的老牌园地，其明确的拒稿范围（纯描述性研究、未作化学表征的植物提取物）在欧洲毒理学刊物中较为少见，长期作为化学致癌与致突变机制研究的发表渠道。