Chemical Research in Toxicology

Chemical Research in Toxicology (commonly abbreviated as Chem. Res. Toxicol.) is a monthly journal from the American Chemical Society, launched in January 1988. It takes the chemical and molecular mechanism of toxic responses as its main line, asking how a toxicant is metabolised, which cellular constituents it binds and how the cell answers, all to be shown with the tools of modern chemical analysis rather than left as description.《化学毒理学研究》（Chemical Research in Toxicology，常用缩写为 Chem. Res. Toxicol.）是美国化学会出版的月刊，1988 年 1 月创刊。刊物把毒理学问题的化学与分子机理作为主线：毒物如何代谢、与细胞的什么成分结合、细胞又如何应答，都要用现代化学分析的手段说清楚，而不是停留在现象描述。

Scope

Under the journal's terms, a submission has to land on mechanism at the chemical and molecular level. Its coverage includes:按刊物的取稿口径，投稿须落到化学与分子层面的机理。收文方向包括：

• Toxicant interactions with living systems: metabolic activation, chemical alteration of cellular constituents and adduct formation, together with specific or nonspecific binding to receptors and enzymes that switches them on or off.毒物与生物系统的相互作用： 代谢活化、细胞组分的化学修饰与加合物形成，以及与受体和酶的特异或非特异结合导致的激活或失活。
• Molecular mechanisms of cellular response: damage and repair of DNA, proteins, lipids and carbohydrates, altered transcription and translation, induction of mutation, activation of stress responses, and cell cycle arrest with apoptosis or necrosis.细胞应答的分子机理： 脱氧核糖核酸、蛋白质、脂质与糖类的损伤和修复、转录翻译的改变、突变的诱发、应激反应的激活、细胞周期阻滞与凋亡或坏死。
• Pathogenesis at organism level: how cellular responses accumulate into tissue injury and disease, covering carcinogenic, neurotoxic and immunotoxic outcomes.机体层面的致病过程： 细胞应答如何累积为组织损伤与疾病发生，致癌、神经毒与免疫毒等结局都在其列。
• Methodology: development and application of new methods for detecting toxicants and assessing exposure, including omics techniques and computational predictive models.方法学： 毒物检测与暴露评估新方法的开发与应用，包括组学技术与计算预测模型的构建与验证。
• Article types: research papers, reviews, perspectives and chemical profiles form the core, with ToxWatch notes, forum pieces and letters appearing irregularly.文章类型： 研究论文、综述、观点与化学画像（Chemical Profiles）为主，毒理观察（ToxWatch）、论坛文章与读者来信不定期出版。

History

• Founding (1988): volume 1 number 1 appeared in January 1988 with the declared aim of moving toxicology from observation to prediction, a stance the journal has kept.创刊（1988年）： 刊物于 1988 年 1 月以第 1 卷第 1 期出版，创刊即确立「从观察毒理走向预测毒理」的取向，这一立场延续至今。
• Change of editor: Shana Sturla of ETH Zurich took the chair from January 2018, succeeding Stephen Hecht.主编更替： 2018 年 1 月起，刊物由苏黎世联邦理工学院的莎娜·斯图拉（Shana Sturla）主持，接替前任斯蒂芬·赫希特（Stephen Hecht）。
• Associate editors: Kate Carroll of the Scripps Research Institute, Jiayin Dai of the Institute of Zoology of the Chinese Academy of Sciences, Annette Kraegeloh of the Leibniz Institute for New Materials, Igor Tetko of the Helmholtz Zentrum München and Yinsheng Wang of the University of California, Riverside.副编辑阵容： 副编辑包括斯克里普斯研究所的凯特·卡罗尔（Kate Carroll）、中国科学院动物研究所的戴佳银、莱布尼茨新材料研究所的安妮特·克雷格洛、赫尔姆霍茨慕尼黑中心的伊戈尔·泰特科与加州大学河滨分校的王寅声。
• Early career board: the first early career board was formed in 2024 for researchers within eight years of their doctorate, charged with spotting new directions and carrying the journal's presence in new media, on two-year renewable terms.青年编委： 2024 年刊物设立首届青年编委，面向获博士学位八年年内的研究者，负责前沿内容策划与新媒体传播，两年一期，可连任。
• Metric trend: the impact factor has moved between 3.2 and 4.1 in recent years and stood at 4.1 in 2025, second quartile in toxicology and third quartile in medicinal chemistry and multidisciplinary chemistry.指标走势： 影响因子近年落在 3.2 至 4.1 之间，2025 年为 4.1，在毒理学类目列二区，药物化学与化学综合列三区。

Editors

The journal runs on an editor-in-chief appointed by the American Chemical Society, with associate editors handling their own areas. No acceptance rate or review duration is published.刊物实行主编负责制，主编由美国化学会任命，副编辑分领域协管稿件；出版方未公布录用比例与审稿时长。

• Editor-in-chief: Shana Sturla, professor at the Department of Health Sciences and Technology of ETH Zurich, working on the quantitative relation between chemical exposure and genetic damage, and winner of the journal's young investigator award in 2014.现任主编： 莎娜·斯图拉（Shana Sturla），苏黎世联邦理工学院健康科学与技术系教授，研究化学暴露引发遗传损伤的定量关系，2014 年获本刊青年研究者毒理奖。
• Disciplinary bounds: a toxicant is defined as any molecule or aggregate of molecules that causes cellular damage, and interactions span metabolism, chemical alteration of cellular constituents, adduct formation and binding to receptors and enzymes.学科边界： 刊物把「毒物」界定为任何造成细胞损伤的分子或其聚集体，「相互作用」则涵盖代谢、细胞组分的化学改变、加合物形成以及与受体和酶的结合。
• Pre-submission enquiry: authors unsure whether a manuscript fits may send an abstract to the editor-in-chief for an opinion before committing to a formal submission.投稿前咨询： 对稿件是否合适没有把握的作者，可先向主编邮箱投递摘要征求意见，再决定是否正式投稿。
• Chemical profile format: large systems-oriented analytical datasets suit the chemical profile format, giving the community reusable material for modelling.化学画像体裁： 大规模系统导向的分析数据集适合以化学画像形式发表，为社群提供可复用的建模素材。