《生物有机化学与医药化学通讯》（Bioorganic & Medicinal Chemistry Letters）是一份经同行评审的科学期刊，专注于快速发表化学生物学、药物化学及药物发现前沿领域的初步研究进展。Bioorganic & Medicinal Chemistry Letters is a peer-reviewed scientific journal dedicated to the rapid publication of preliminary accounts of research at the interface of chemistry and biology, medicinal chemistry, and drug discovery. 该期刊由爱思唯尔（Elsevier）出版，作为《生物有机化学与医药化学》（Bioorganic & Medicinal Chemistry）的快报类姊妹刊而设立。Published by Elsevier, the journal was established as a rapid-communications sister journal to Bioorganic & Medicinal Chemistry.
该期刊涵盖了化学结构与生物功能交叉领域的研究，尤其关注具有生物活性的分子设计与合成。The scope of the journal encompasses research at the intersection of chemical structure and biological function, with a particular focus on the design and synthesis of biologically active molecules. 其主要收录范围包括药效团识别、受体与配体相互作用、结构活性关系（SAR）研究以及分子靶向药物的开发。Key areas of coverage include pharmacophore identification, receptor-ligand interactions, structure-activity relationship (SAR) studies, and the development of targeted therapeutics. 期刊文章通常以简短通讯（Letters）的形式呈现，强调实验结果的时效性、独创性与即时学术价值。Articles are typically presented in the concise format of letters, emphasizing timeliness, originality, and the immediate impact of experimental findings.
该期刊于1991年由珀加蒙出版社（Pergamon Press）创刊，随后随着该出版社被兼并而纳入爱思唯尔旗下。The journal was established in 1991 by Pergamon Press and subsequently integrated into Elsevier following an acquisition. 它的创办满足了科学界对能够快速通报前沿药物化学合成与药理学发现的专业出版平台的迫切需求。Its founding answered a growing demand within the scientific community for a specialized platform capable of rapidly announcing cutting-edge synthetic and pharmacological discoveries. 随着全球学术传播向数字化转型，该期刊完全接入了ScienceDirect平台，并逐步演进以支持开放获取出版模式。Over decades of publication, the journal fully transitioned to digital dissemination via ScienceDirect and evolved to support open-access publishing models.
该刊创刊时的执行主编是哈佛大学已故杰出化学家白川英树之合作导师、知名学者艾里亚斯·詹姆斯·科里（E. J. Corey）。The founding Executive Editor of the journal was Elias James Corey, the renowned Harvard University chemist and Nobel laureate. 如今，该期刊由多位国际知名的药物化学家共同担任主编与学术编辑，负责协调各个专业研究领域的同行评审工作。Today, the journal is managed by internationally recognized medicinal chemists who serve as Editors and Associate Editors across diverse subdisciplines. 在现任编辑领导团队中，斯克里普斯研究所（The Scripps Research Institute）的戴维·博格（Dale L. Boger）等学者长期担任执行编辑与顾问职务，确保了期刊严格的学术质量把控。Notable long-standing editorial leadership has included prominent figures such as Dale L. Boger of The Scripps Research Institute, maintaining rigorous standards of peer review.