《生物有机化学与药物化学》（Bioorganic & Medicinal Chemistry）是一份经过同行评审的科学期刊，由爱思唯尔出版。Bioorganic & Medicinal Chemistry is a peer-reviewed scientific journal published by Elsevier.
该期刊涵盖化学生物学、药物化学与药物发现交界领域的研究。The journal covers research at the interface of chemical biology, medicinal chemistry, and drug discovery.
《生物有机化学与药物化学》发表关注在分子水平上阐明生物学过程的化学研究全篇论文。Bioorganic & Medicinal Chemistry publishes full-length research articles focusing on chemical studies that elucidate biological processes at the molecular level.
该刊的主要范围包括先导化合物结构设计与优化、作用机制研究以及定量构效关系分析。The main scope includes rational design and optimization of lead compounds, studies on mechanisms of action, and quantitative structure-activity relationship analyses.
重点涵盖的领域还包括天然产物化学、靶向化学生物学探针开发以及生物大分子与小分子相互作用研究。Covered areas also include natural product chemistry, development of targeted chemical biological probes, and investigations into macromolecule-small molecule interactions.
该期刊不仅刊登原创研究论文，还定期发表由领域专家撰写的权威特邀综述和专题文章。In addition to original research papers, the journal regularly features authoritative invited reviews and themed perspective articles written by leading experts in the field.
该期刊于1993年由佩加蒙出版社（Pergamon Press）创立，旨在促进化学与生物学交叉学科的研究发表。The journal was established in 1993 by Pergamon Press to facilitate publication in the multidisciplinary field between chemistry and biology.
随着爱思唯尔对佩加蒙出版社的整合，该刊成为爱思唯尔旗下药物化学与生命科学学术出版组合的核心期刊之一。Following Elsevier's integration of Pergamon Press, the journal became a core publication in Elsevier's medicinal chemistry and life sciences publishing portfolio.
创刊初期，它与姐妹期刊《生物有机化学与药物化学快报》（Bioorganic & Medicinal Chemistry Letters）相呼应，分别承担长篇论文和快速简报的出版功能。In its early years, it served alongside its sister journal, Bioorganic & Medicinal Chemistry Letters, with the former focusing on full-length papers and the latter on rapid communications.
几十年来，该刊见证了药物发现范式从传统表型筛选向现代靶向化学基因组学与结构生物学导向设计的演进。Over several decades, the journal has witnessed the evolution of drug discovery paradigms from traditional phenotypic screening to modern chemogenomics and structure-guided design.
期刊的创刊主编是哥伦比亚大学著名天然产物化学家中西香尔（Koji Nakanishi）。The founding Editor-in-Chief of the journal was Koji Nakanishi, a renowned natural products chemist from Columbia University.
目前该刊采用由执行编辑（Executive Editors）与专业副主编组成的学术编辑委员会负责稿件的同行评议。The journal currently operates with an academic editorial board of Executive Editors and specialized associate editors who oversee the peer review process.
现任资深学术编辑包括来自乌得勒支大学的 Rob M. J. Liskamp 以及来自普渡大学等知名研究机构的资深科学家。Current senior academic editors include Rob M. J. Liskamp from Utrecht University alongside distinguished scientists from institutions such as Purdue University.
编辑团队协同庞大的国际顾问委员会，负责监督论文评审质量并指导期刊的学术方向。The editorial team works in concert with an international advisory board to oversee manuscript quality and steer the academic direction of the journal.