Biomedical Optics Express

《Biomedical Optics Express》是 2010 年创办的开放获取月刊，由美国光学学会的出版部门出版。

刊物面向生物医学光学，发表从基础研究、技术开发到临床应用的完整链条，并把方法创新与生物医学问题放在同等位置。

2025 年期刊影响因子为 3.2，五年影响因子为 3.2，在光学 129 种期刊中排第 51 位。

Scope

• Tissue optics and spectroscopy form the physical core, covering light transport, absorption and scattering in biological media.组织光学与光谱学构成物理核心，涵盖生物介质中的光传输、吸收与散射。
• Novel microscopies are reported, from multiphoton and light-sheet methods to super-resolution and label-free imaging.新型显微方法得到报道，从多光子与光片方法到超分辨与无标记成像。
• Optical coherence tomography is a standing subject, with papers on system design, contrast agents and clinical imaging of the eye and vasculature.光学相干断层成像是常设题目，论文涉及系统设计、造影剂以及眼与血管的临床成像。
• Diffuse and fluorescence tomography papers address reconstruction, calibration and quantification in thick tissue.漫射与荧光断层成像论文讨论厚组织中的重建、校准与定量。
• Photoacoustic and multimodal imaging combine optical contrast with acoustic resolution, and are evaluated against established modalities.光声与多模态成像把光学对比与声学分辨率结合，并与既有成像手段作对照。
• Molecular imaging and light-based therapy include targeted probes, photodynamic treatment and dosimetry for light delivery.分子成像与光治疗包括靶向探针、光动力治疗以及光照剂量的计量。
• Nanophotonic biosensing covers plasmonic and dielectric resonators, single-molecule detection and point-of-care assay formats.纳米光子生物传感涵盖等离激元与介质谐振器、单分子检测以及床旁检测形式。
• Optical biophysics and photobiology study light-induced effects in cells and tissue, including phototoxicity and optogenetics.光学生物物理与光生物学研究光在细胞与组织中的作用，包括光毒性与光遗传学。
• Microfluidic optical devices integrate channels with detection optics for small-volume and single-cell analysis.微流控光学器件把通道与检测光学集成，用于小体积与单细胞分析。
• Vision research appears through retinal imaging, ophthalmic diagnostics and the optics of the eye.视觉研究通过视网膜成像、眼科诊断与眼的光学特性进入刊物。
• Endoscopic and catheter-based optics are published when the device is characterised and tested in tissue or in vivo.内镜与导管光学在器件得到表征并在组织或活体中测试时被发表。
• Wearable and implantable photonic sensors are judged on stability, biocompatibility and calibration over time.可穿戴与植入式光子传感器以稳定性、生物相容性与长期校准作为评判标准。
• Computational imaging papers must show that reconstruction gains survive noise and mismatch rather than only in simulation.计算成像论文须证明重建收益在噪声与失配下仍然成立，而不只在仿真中成立。
• Machine learning is used for segmentation, denoising and inverse problems, with data splits and generalisation reported.机器学习被用于分割、去噪与反问题，并要求报告数据划分与泛化表现。
• Translation studies report phantom, ex vivo and first-in-human results in sequence, so that each step is independently checkable.转化研究报告体模、离体与首次人体结果，按顺序给出以便逐步独立核查。
• Papers are expected to release code or data where licensing allows, and to describe optical calibration in enough detail to repeat it.在许可允许时论文须公开代码或数据，并把光学校准写到可以重复的程度。
• Reviews and tutorials introduce a technique to readers outside its home community and are commissioned or invited.综述与教程把某项技术介绍给本领域之外的读者，通常由编辑约请。
• Clinical validation work is welcomed even when the optical method is mature, provided the study answers a diagnostic or therapeutic question.即使光学方法已经成熟，只要研究回答诊断或治疗问题，临床验证工作同样受欢迎。

• Light-sheet and adaptive-optics microscopy papers report resolution, penetration depth and photobleaching together, so that the trade-offs remain visible.光片与自适应光学显微论文同时报告分辨率、穿透深度与光漂白，使取舍关系清晰可见。
• Optical biosensors for infection and cancer markers are evaluated on limit of detection and on performance in clinical samples.面向感染与肿瘤标志物的光学生物传感器以检出限与临床样本中的表现作为评价依据。

History

• The journal was launched in 2010 by the Optical Society of America as an open-access title for biomedical optics.该刊于 2010 年由美国光学学会创办，作为生物医学光学的开放获取期刊。
• It was conceived as the society's principal outlet for the biomedical optics community, alongside the broader optics journals.刊物被设想为学会面向生物医学光学界的主要出口，与覆盖更广的光学期刊并列。
• Joseph Izatt of Duke University was the founding editor, and optical coherence tomography shaped the journal's early identity.杜克大学的 Joseph Izatt 是创刊编辑，光学相干断层成像塑造了刊物早期的面貌。
• Every article is published under a Creative Commons licence, and authors retain copyright in their work.所有文章都在知识共享许可下发布，作者保留著作权。
• Authors pay an article processing charge, and the journal has no subscription barrier for readers.作者支付文章处理费，读者端没有任何订阅门槛。
• The society rebranded as Optica in 2021, and its publishing arm became Optica Publishing Group.学会于 2021 年更名为 Optica，其出版部门随之称为 Optica Publishing Group。
• Articles appear continuously within monthly issues, so accepted papers reach readers before the issue is closed.文章在月刊内连续发表，被接受的论文在成期之前就能与读者见面。
• Impact factors ran at 3.732 in 2021, 3.562 in 2022, 2.9 in 2023, then 3.2 in 2024 and 2025.影响因子在 2021 年为 3.732，2022 年为 3.562，2023 年为 2.9，2024 年与 2025 年均为 3.2。
• The 2025 report counted 16194 citations, 348 articles and 353 citable items.2025 年报告统计该刊被引 16194 次，论文 348 篇，可引用条目 353 项。
• Almost all recent content is gold open access, and the journal is listed in the Directory of Open Access Journals.近期内容几乎全部为金色开放获取，刊物被开放获取期刊目录收录。
• The title is indexed in the Science Citation Index Expanded, Scopus and PubMed Central, and appears in three JCR categories.该刊被科学引文索引扩展版、Scopus 与 PubMed Central 收录，并在三个 JCR 类别中出现。
• Its three categories are biochemical research methods, optics, and radiology, nuclear medicine and medical imaging.这三个类别分别是生化研究方法、光学，以及放射学、核医学与医学影像。
• Manuscripts are submitted and tracked through the publisher's Prism system, and reviewers are asked to judge both the optics and the biological relevance.稿件通过出版方的 Prism 系统提交与跟踪，审稿人须同时评判光学工作与生物学相关性。

Editors

• Ruikang Wang of the University of Washington is editor-in-chief, known for optical coherence tomography and Doppler flow imaging.华盛顿大学的 Ruikang Wang 是现任主编，以光学相干断层成像与多普勒血流成像知名。
• Joseph Izatt of Duke University, the founding editor, remains associated with the journal as a reviews editor.创刊编辑、杜克大学的 Joseph Izatt 仍以综述编辑的身份与刊物保持联系。
• Kostadinka Bizheva of Waterloo works on ophthalmic coherence imaging and cellular-resolution retinal imaging.滑铁卢大学的 Kostadinka Bizheva 研究眼科相干成像与细胞分辨率的视网膜成像。
• Regine Choe at Rochester develops diffuse optical methods for breast imaging and for monitoring treatment response.罗切斯特大学的 Regine Choe 开发用于乳腺成像与疗效监测的漫射光学方法。
• Hamid Dehghani at Birmingham works on image reconstruction for diffuse optical tomography.伯明翰大学的 Hamid Dehghani 研究漫射光学断层成像的图像重建。
• Sina Farsiu at Duke applies computer vision and machine learning to retinal images.杜克大学的 Sina Farsiu 把计算机视觉与机器学习用于视网膜图像。
• Pietro Ferraro of the Italian National Research Council works on digital holography and quantitative phase imaging.意大利国家研究委员会的 Pietro Ferraro 研究数字全息与定量相位成像。
• James Fujimoto of MIT, a pioneer of optical coherence tomography, sits on the advisory board.光学相干断层成像的先驱、麻省理工学院的 James Fujimoto 在顾问委员会任职。
• Min Gu and Stefan Hell bring nanophotonics and super-resolution microscopy to the advisory group.顾敏与 Stefan Hell 把纳米光子学与超分辨显微带入顾问团队。
• Rebecca Richards-Kortum and Eva Sevick-Muraca advise on low-cost diagnostics and fluorescence imaging respectively.Rebecca Richards-Kortum 与 Eva Sevick-Muraca 分别就低成本诊断与荧光成像提供建议。
• Alfred Vogel and David Williams contribute laser-tissue interaction and vision science, and Arjun Yodh brings diffuse optics.Alfred Vogel 与 David Williams 分别带来激光与组织相互作用和视觉科学，Arjun Yodh 带来漫射光学。
• Associate editors handle the review and are expected to judge whether a device claim is supported by tissue measurement.副编辑负责评审，并须判断器件的声明是否有组织实测数据支持。
• The editorial office asks for a data availability statement and screens image integrity before a paper is sent out.编辑部要求提供数据可用性声明，并在送审前筛查图像完整性。