Annual Review of Pharmacology and Toxicology

Annual Review of Pharmacology and Toxicology publishes authoritative review articles spanning pharmacology and toxicology, from molecular mechanisms of drug action to the assessment of chemical hazards and therapeutic risk.《药理学与毒理学年鉴》（Annual Review of Pharmacology and Toxicology）发表横跨药理学与毒理学的权威性综述，从药物作用的分子机制到化学危害与治疗风险的评估。

Scope

The journal's stated aim is to provide authoritative reviews covering significant developments in pharmacology and toxicology, with its official scope covering:刊物官方宗旨为发表涵盖药理学与毒理学重要进展的权威性综述，官方声明的征稿范围包括：

• Pharmacodynamics and drug action: reviews on receptors, transporters, enzymes, and ion channels as drug targets, together with the signalling pathways and mechanisms through which drugs exert their therapeutic and adverse effects.药效学与药物作用： 受体、转运体、酶与离子通道等药物靶点，以及药物发挥治疗与不良反应所经的信号通路与机制等方向的综述。
• Pharmacokinetics and drug development: reviews on the absorption, distribution, metabolism, and excretion of drugs, pharmacogenomics, precision medicine, and the process of drug discovery and development from target identification to clinical trials.药代动力学与药物开发： 药物的吸收、分布、代谢与排泄，药物基因组学，精准医学，以及从靶点发现到临床试验的药物研发流程等方向的综述。
• Toxicology and risk assessment: reviews on the mechanisms of toxicity, toxicogenomics, the ADME of toxicants, environmental and occupational exposure, chemical risk assessment, and the safety evaluation of drugs and chemicals.毒理学与风险评估： 毒性机制、毒理基因组学、毒物的 ADME、环境与职业暴露、化学品风险评估以及药物与化学品安全性评价等方向的综述。
• Systems-level pharmacology: reviews on the pharmacology of the nervous, cardiovascular, immune, endocrine, and gastrointestinal systems, together with the integration of pharmacology and toxicology in therapeutic development.系统层面药理学： 神经、心血管、免疫、内分泌与胃肠等系统的药理学，以及药理学与毒理学在治疗开发中的整合等方向的综述。
• Review model: articles are invited by the editorial committee and organised by theme, with each volume addressing a selected set of topics chosen for their timeliness and impact.综述模式： 文章由编委会邀约并按主题组织，每卷围绕一组具有时效性与影响力的选定议题展开。

History

• Founding: volume 1 appeared in 1961 under the name Annual Review of Pharmacology, with Windsor C. Cutting as founding editor. Cutting was also the founding editor of the Annual Review of Medicine.创刊： 1961 年第 1 卷以《药理学年鉴》（Annual Review of Pharmacology）之名出版，由温莎·卡廷（Windsor C. Cutting）担任创刊主编；卡廷同时也是《内科医学年鉴》的创刊主编。
• Title expansion: from volume 16 in 1976 the journal was renamed the Annual Review of Pharmacology and Toxicology, formally incorporating toxicology into its scope to reflect the growing importance of the field at the interface of pharmacology and public health.刊名扩展： 1976 年第 16 卷起更名为《药理学与毒理学年鉴》，将毒理学正式纳入刊物范围，以反映该领域在药理学与公共卫生交界处日益增长的重要性。
• Publisher continuity: the journal has been published continuously by Annual Reviews in Palo Alto, California, maintaining the organisation's signature model of invited, peer-reviewed annual review volumes across the life sciences.出版沿革： 该刊一直由加州帕洛阿尔托的 Annual Reviews 出版，延续该机构在生命科学领域特邀、同行评审年度综述卷的标志性模式。

Editors

The journal is led by a team of co-editors supported by associate editors and an editorial committee, drawn from leading pharmacology and toxicology departments worldwide:该刊由联合主编团队领导，副编辑与编委会协助，成员来自全球顶尖药理学与毒理学机构：

• Co-editors: Paul A. Insel of the University of California, San Diego, whose research focuses on G-protein-coupled receptors and adrenergic signalling. Amrita Ahluwalia of Queen Mary University of London, whose research focuses on vascular pharmacology and sex differences in drug responses. Susan G. Amara, whose research focuses on neurotransmitter transporters and psychostimulant action.联合主编： 加州大学圣迭戈分校的保罗·因塞尔（Paul A. Insel），研究方向为 G 蛋白偶联受体与肾上腺素能信号传导；伦敦玛丽女王大学的阿姆丽塔·阿卢瓦利亚（Amrita Ahluwalia），研究方向为血管药理学与药物反应的性别差异；以及苏珊·阿马拉（Susan G. Amara），研究方向为神经递质转运体与精神兴奋剂作用。
• Thematic organisation: each volume is organised around a central theme chosen by the co-editors, such as novel therapeutics with the potential to advance health care, ensuring that the reviews address coherent and timely questions.主题组织： 每卷围绕联合主编选定的中心主题组织，例如有望推动医疗保健的新型治疗，确保综述围绕连贯且及时的问题展开。
• Invitation and review: authors are invited by the editors based on their expertise in the chosen theme, and submitted manuscripts undergo peer review before being included in the annual volume.邀约与评审： 编辑根据作者在选定主题方面的专长进行邀约，投稿经同行评审后编入年度卷。