Annual Review of Pathology-Mechanisms of Disease
Annual Review of Pathology: Mechanisms of Disease is an annual peer-reviewed journal published by Annual Reviews, covering significant advances in understanding the initiation and progression of human diseases. Founded in 2006, it is a leading review journal in pathology, with a 2025 impact factor of 34.5, indexed in SCIE.《病理学年度评论：疾病机制》（Annual Review of Pathology: Mechanisms of Disease）是由 Annual Reviews 出版的年度同行评审期刊，涵盖理解人类疾病发生与进展的重要进展。该刊创刊于 2006 年，是病理学领域的领军综述期刊，2025 年影响因子为 34.5，被 SCIE 收录。
Scope
The journal's stated aim is to cover significant advances in understanding the initiation and progression of important human diseases, with its official scope covering:刊物官方宗旨为涵盖理解重要人类疾病发生与进展的重要进展，官方声明的征稿范围包括：
- Disease pathogenesis: reviews on current and evolving concepts of disease pathogenesis, including the cellular and molecular mechanisms underlying disease initiation and progression.疾病发病机制： 关于疾病发病机制当前与演进概念的综述，涵盖疾病发生与进展背后的细胞与分子机制。
- Molecular genetic alterations: reviews on the molecular genetic alterations associated with diseases, including genomic, transcriptomic, and proteomic changes in pathological conditions.分子遗传学改变： 关于与疾病相关的分子遗传学改变的综述，涵盖病理状态下的基因组、转录组与蛋白质组变化。
- Morphologic alterations: reviews on the morphologic and histopathologic alterations associated with diseases, integrating structural changes with molecular and clinical findings.形态学改变： 关于与疾病相关的形态学与组织病理学改变的综述，将结构变化与分子和临床发现相结合。
- Clinical significance: reviews that connect pathogenetic mechanisms to clinical significance, including diagnostic, prognostic, and therapeutic implications.临床意义： 关于将发病机制与临床意义（包括诊断、预后与治疗意义）相联系的综述。
- Article types: annual comprehensive review articles, each providing an authoritative synthesis of significant advances in a specific area of pathology and disease mechanisms.栏目设置： 每年发表综合性综述文章，每篇对病理学与疾病机制某一特定领域的重要进展进行权威综述。
History
- Founding: the Annual Review of Pathology: Mechanisms of Disease was founded in 2006 by Annual Reviews, with its first volume published in February 2006.创刊： 《病理学年度评论：疾病机制》于 2006 年由 Annual Reviews 创办，首卷于 2006 年 2 月出版。
- Annual Reviews publication: the journal is part of the Annual Reviews series of review journals, applying the consistent model of annual, authoritative, invited review articles.Annual Reviews 出版： 该刊是 Annual Reviews 综述期刊系列的一部分，采用每年发表权威特邀综述的统一模式。
- Disease mechanism focus: from its founding the journal has focused on the mechanisms of disease, bridging basic science and clinical pathology to provide a comprehensive understanding of human disease.疾病机制定位： 自创刊起该刊即聚焦于疾病机制，架起基础科学与临床病理学之间的桥梁，以提供对人类疾病的全面理解。
- High impact: since its founding the journal has become one of the most highly cited and influential journals in pathology, consistently ranking among the top pathology journals by impact factor.高影响力： 自创刊以来该刊已成为病理学领域被引最高、最具影响力的期刊之一，影响因子长期位居病理学期刊前列。
Editors
The journal is led by an editor-in-chief and a co-editor supported by an editorial committee:该刊由主编与联合编辑领导，编辑委员会协助工作：
- Editor-in-chief: Jon C. Aster serves as the editor-in-chief, overseeing the journal's editorial direction in pathology and disease mechanisms.主编： 乔恩·C. 阿斯特（Jon C. Aster）担任主编，负责该刊在病理学与疾病机制方向的编辑工作。
- Co-editor: Mel B. Feany, Professor of Pathology at Harvard Medical School and Brigham and Women's Hospital, serves as co-editor, with expertise in neurodegenerative disease pathology.联合编辑： 哈佛医学院与布莱根妇女医院病理学教授梅尔·B. 菲尼（Mel B. Feany）担任联合编辑，专长于神经退行性疾病病理学。
- Editorial committee: the journal is guided by an editorial committee comprising leading pathologists and disease mechanism researchers from institutions worldwide.编辑委员会： 该刊由来自全球机构的顶尖病理学家与疾病机制研究人员组成的编辑委员会指导。
- Review process: invited manuscripts undergo editorial review and revision, with the editors working closely with authors to ensure the highest quality and comprehensiveness of each review.评审流程： 特邀稿件经过编辑评审与修改，编辑与作者密切合作以确保每篇综述的最高质量与全面性。