ACS Medicinal Chemistry Letters

ACS Medicinal Chemistry Letters is the monthly letter journal of the American Chemical Society on medicinal chemistry, published from Washington, D.C., with a 2025 Journal Impact Factor of 3.9《ACS Medicinal Chemistry Letters》是美国化学会关于药物化学的月刊短篇刊物，在华盛顿特区出版，2025 年影响因子为 3.9。

Scope

• The journal reports new findings in drug discovery, compound design and optimization, biological evaluation, drug delivery, imaging agents and pharmacology, and it accepts studies on compound design and optimization, biological evaluation, drug delivery, imaging agents, drug interactome studies and the pharmacology of both small and large bioactive molecules该刊报道药物发现、化合物设计与优化、生物评价、药物递送、成像探针与药理学方面的新发现，接收的研究涉及化合物设计与优化、生物评价、药物递送、成像探针、药物互作组研究，以及小分子与大分子生物活性分子的药理学。

• Specific areas it names include the identification, synthesis and optimization of lead biologically active molecules and drugs, the biological characterization of new molecular entities in the context of drug discovery so as to delineate structure-activity relationship trends, and the computational, cheminformatics and structural studies used to identify bioactive molecules, ligands and their targets or to analyse their structure-activity relationships期刊点名的具体方向包括先导生物活性分子与药物的鉴定、合成与优化，在药物发现语境下表征新分子实体以揭示构效关系趋势，以及用于鉴定生物活性分子、配体及其靶标或分析其构效关系的计算、化学信息学与结构研究。

• It also takes the use of artificial intelligence and machine learning in drug discovery, novel and improved methodologies including radiation biochemistry where these have been tested on relevant molecules, and new developments in screening and bioassay technologies for biologically active molecules from synthetic and natural sources刊物也接收药物发现中人工智能与机器学习的使用、包括放射生物化学在内的新方法与改进方法（前提是在相关分子上做过检验），以及针对合成来源与天然来源生物活性分子的筛选与生物测定技术的新进展。

• Chemically relevant patents, studies involving proximity-inducing agents such as targeted protein degradation and molecular glues, and novel mechanism of action work on previously published investigational or approved drugs are in scope, the last of these provided the result is confirmed by at least two independent assays与药物化学相关的化学专利、涉及靶向蛋白降解与分子胶等邻近诱导剂的研究，以及对既往已发表在研或已获批药物的新作用机制研究都在其列，最后一类须有至少两种独立测定加以确证。

History

• The journal began with volume 1, number 1 in April 2010 as a title of the American Chemical Society, the National Library of Medicine catalog recording the imprint as Washington, D.C., American Chemical Society from 2009 and noting that some articles in the 2010 volume appeared electronically in 2009该刊自 2010 年 4 月的第 1 卷第 1 期起步，是美国化学会旗下的刊物，美国国家医学图书馆目录记载出版者为位于华盛顿特区的美国化学会，出版起始年记为 2009 年，并注明 2010 年卷的部分文章早在 2009 年即已电子发布。

• It appears monthly, and volume 17, number 10 came out in October 2026, the web edition ISSN 1948-5875 being the only identifier the journal's own pages give该刊每月出版，2026 年 10 月出至第 17 卷第 10 期，刊页给出的唯一标识是网络版 ISSN 1948-5875。

• The same catalog also carries the journal under the alternative titles Medicinal Chemistry Letters and American Chemical Society Medicinal Chemistry Letters同一份目录另以《Medicinal Chemistry Letters》和《American Chemical Society Medicinal Chemistry Letters》两个名称著录该刊。

• The journal's own metrics page for 2025 gives a two-year and a five-year Impact Factor of 3.9, a CiteScore of 5.6, 10 525 citations and 1 372 885 article downloads, with the journal indexed by PubMed, Web of Science Science Citation Index Expanded, Scopus, CAS and Portico该刊自设的 2025 年指标页给出两年与五年影响因子同为 3.9、CiteScore 5.6、总被引 10 525 次、文章下载 1 372 885 次，刊物被 PubMed、Web of Science 的 Science Citation Index Expanded、Scopus、CAS 与 Portico 收录。

• The same page reports the median time from submission to first peer review decision as 26.2 days, to acceptance as 60.4 days and from acceptance to publication as 5.9 days同一页面报告，从投稿到首次评审决定的中位时间为 26.2 天，到录用的中位时间为 60.4 天，从录用到发表的中位时间为 5.9 天。

Editors

• Kelly Chibale is editor in chief, holding the Neville Isdell Chair in African-centric Drug Discovery and Development and a professorship of organic chemistry at the University of Cape Town in South Africa主编为 Kelly Chibale，其担任南非开普敦大学的 Neville Isdell 非洲中心药物发现与开发讲席以及有机化学教授。

• His research lies in global health infectious disease drug discovery and in the development of preclinical discovery tools and models meant to improve treatment outcomes for people of African heritage其研究集中于全球卫生领域的传染病药物发现，以及为改善非洲裔人群治疗结果而开发的临床前发现工具与模型。

• The journal reaches him at a dedicated address for the editor in chief, and the American Chemical Society publishes the full editorial board of the journal on a separate page linked from every issue刊物为主编单设电子信箱，美国化学会在各期所链接的专页上公布本刊的完整编委名单。

• The American Chemical Society runs the submission and publishing workflow for its journals on shared systems, and the journal's own page carries the metrics that show how quickly manuscripts move from submission to publication美国化学会为旗下刊物统一使用投稿与出版系统办理流程，本刊页面所列指标正反映稿件从投稿到发表的流转速度。

• The journal's own description of its purpose is to report new findings, and the letter format in which those findings appear keeps the reporting of them compact该刊自述其宗旨是报道新发现，承载这些发现的通报表例使其呈现保持紧凑。