《ACS组合科学》（ACS Combinatorial Science）是一份由美国化学会出版的同行评审科学期刊。ACS Combinatorial Science was a peer-reviewed scientific journal published by the American Chemical Society.
该期刊主要报道组合方法学、高通量筛选与合成及自动化技术在多学科中的发展与应用。The journal focused on the development and application of combinatorial methodologies, high-throughput screening and synthesis, and automation technologies across multiple disciplines.
该刊发表涉及化学、生物学和材料科学等领域的原创研究论文、简报、综述及观点文章。The journal published original research articles, communications, reviews, and perspective pieces spanning chemistry, biology, and materials science.
其核心报道方向包括分子文库设计、高通量合成与纯化，以及适用于先导化合物和功能催化剂的高通量表征手段。Its core scope covered molecular library design, high-throughput synthesis and purification, and rapid characterization tools for lead compounds and functional catalysts.
此外，该期刊还着重涵盖微流控芯片技术、组合材料开发、化学生物学探针发现以及用于大型数据集分析的计算工具。Additionally, it highlighted microfluidic technologies, combinatorial materials discovery, chemical biology probe identification, and computational methods for large-scale dataset analysis.
该期刊于1999年创刊，最初定名为《组合化学杂志》（Journal of Combinatorial Chemistry）。The journal was established in 1999 under the original title Journal of Combinatorial Chemistry.
2011年，期刊更名为《ACS组合科学》，以体现学科范畴从传统有机合成向多学科高通量科学与材料发现的拓展。In 2011, the publication was renamed ACS Combinatorial Science to reflect an expanded scope beyond organic synthesis into interdisciplinary high-throughput science and materials discovery.
该期刊于2020年12月停刊，相关研究方向被美国化学会旗下的其他相关学科期刊整合与吸收。The journal ceased publication in December 2020, with its research topics subsequently integrated into other American Chemical Society journals.
安东尼·W·恰尔尼克（Anthony W. Czarnik）担任《组合化学杂志》时期的创刊主编，主持该刊初创阶段的发展。Anthony W. Czarnik served as the founding editor-in-chief during its tenure as the Journal of Combinatorial Chemistry, guiding its initial development.
2011年更名后，佐治亚理工学院化学教授M·G·芬恩（M. G. Finn）接任主编职务。Following the renaming in 2011, M. G. Finn, a chemistry professor at the Georgia Institute of Technology, assumed the position of editor-in-chief.
芬恩在此职位上持续主持该刊的审稿与编辑工作，直至期刊在2020年最终停刊。Finn remained at the helm, directing editorial operations and peer review until the journal concluded publication in 2020.